A virtual hair cell, I: Addition of gating spring theory into a 3-D bundle mechanical model

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dc.contributorVirginia Techen
dc.contributor.authorNam, Jong-Hoonen
dc.contributor.authorCotton, John R.en
dc.contributor.authorGrant, John Wallaceen
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessed2014-02-05en
dc.date.accessioned2014-02-26T19:10:05Zen
dc.date.available2014-02-26T19:10:05Zen
dc.date.issued2007-03-01en
dc.description.abstractWe have developed a virtual hair cell that simulates hair cell mechanoelectrical transduction in the turtle utricle. This study combines a full three-dimensional hair bundle mechanical model with a gating spring theory. Previous mathematical models represent the hair bundle with a single degree of freedom system which, we have argued, cannot fully explain hair bundle mechanics. In our computer model, the tip link tension and fast adaptation modulator kinetics determine the opening and closing of each channel independently. We observed the response of individual transduction channels with our presented model. The simulated results showed three features of hair cells in vitro. First, a transient rebound of the bundle tip appeared when fast adaptation dominated the dynamics. Second, the dynamic stiffness of the bundle was minimized when the response-displacement (I-X) curve was steepest. Third, the hair cell showed "polarity'', i. e., activation decreased from a peak to zero as the forcing direction rotated from the excitatory to the inhibitory direction.en
dc.description.sponsorshipNational Institutes of Health NIDCD R01 DC 05063, NIDCD R01 DC 002290-12en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationNam, Jong-Hoon; Cotton, John R.; Grant, Wally. "A virtual hair cell, I: Addition of gating spring theory into a 3-D bundle mechanical model," Biophysical Journal 92(6), 1918-1928 (2007); doi: 10.1529/biophysj.106.085076en
dc.identifier.doihttps://doi.org/10.1529/biophysj.106.085076en
dc.identifier.issn0006-3495en
dc.identifier.urihttp://hdl.handle.net/10919/25777en
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0006349507709992en
dc.language.isoen_USen
dc.publisherCELL PRESSen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectMechanoelectrical-transduction channelsen
dc.subjectBullfrogs sacculusen
dc.subjectMechanotransducer channelen
dc.subjectSpontaneous oscillationen
dc.subjectComputationalen
dc.subjectModelsen
dc.subjectCa2+ concentrationen
dc.subjectCiliary bundlesen
dc.subjectInner-earen
dc.subjectAdaptationen
dc.subjectStereociliaen
dc.titleA virtual hair cell, I: Addition of gating spring theory into a 3-D bundle mechanical modelen
dc.title.serialBiophysical Journalen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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