Writing DNA with GenoCAD (TM)

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dc.contributor.authorCzar, Michael J.en
dc.contributor.authorCai, Yizhien
dc.contributor.authorPeccoud, Jeanen
dc.date.accessioned2019-04-18T14:46:56Zen
dc.date.available2019-04-18T14:46:56Zen
dc.date.issued2009-07-01en
dc.description.abstractChemical synthesis of custom DNA made to order calls for software streamlining the design of synthetic DNA sequences. GenoCAD (TM) (www.genocad.org) is a free web-based application to design protein expression vectors, artificial gene networks and other genetic constructs composed of multiple functional blocks called genetic parts. By capturing design strategies in grammatical models of DNA sequences, GenoCAD guides the user through the design process. By successively clicking on icons representing structural features or actual genetic parts, complex constructs composed of dozens of functional blocks can be designed in a matter of minutes. GenoCAD automatically derives the construct sequence from its comprehensive libraries of genetic parts. Upon completion of the design process, users can download the sequence for synthesis or further analysis. Users who elect to create a personal account on the system can customize their workspace by creating their own parts libraries, adding new parts to the libraries, or reusing designs to quickly generate sets of related constructs.en
dc.description.notesVirginia Commonwealth Research Initiative; fellowship from the Virginia Tech Genetics, Bioinformatics and Computational Biology graduate program awarded to YC. Funding for open access charge: Virginia Bioinformatics Institute.en
dc.description.sponsorshipVirginia Commonwealth Research Initiative; Virginia Tech Genetics; Bioinformatics and Computational Biology; Virginia Bioinformatics Instituteen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/nar/gkp361en
dc.identifier.eissn1362-4962en
dc.identifier.issn0305-1048en
dc.identifier.pmid19429897en
dc.identifier.urihttp://hdl.handle.net/10919/89030en
dc.identifier.volume37en
dc.language.isoen_USen
dc.rightsCreative Commons Attribution-NonCommercial 2.0 Genericen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/2.0/en
dc.subjectsynthetic biologyen
dc.subjectgene-expressionen
dc.subjectchemical-synthesisen
dc.subjectescherichia-colien
dc.subjectglobal analysisen
dc.subjecttoggle switchen
dc.subjectdesignen
dc.subjectpartsen
dc.subjectgenomeen
dc.subjectvirusen
dc.titleWriting DNA with GenoCAD (TM)en
dc.title.serialNucleic Acids Researchen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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