Utility of Tissue Doppler Imaging in the Echocardiographic Evaluation of Left and Right Ventricular Function in Dogs with Myxomatous Mitral Valve Disease with or without Pulmonary Hypertension

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dc.contributor.authorToaldo, M. Baronen
dc.contributor.authorPoser, H.en
dc.contributor.authorMenciotti, Giulioen
dc.contributor.authorBattaia, S.en
dc.contributor.authorContiero, B.en
dc.contributor.authorCipone, M.en
dc.contributor.authorDiana, A.en
dc.contributor.authorMazzotta, E.en
dc.contributor.authorGuglielmini, C.en
dc.date.accessioned2019-08-07T18:40:02Zen
dc.date.available2019-08-07T18:40:02Zen
dc.date.issued2016-05en
dc.description.abstractBackground: In human medicine, right ventricular (RV) functional parameters represent a tool for risk stratification in patients with congestive heart failure caused by left heart disease. Little is known about RV alterations in dogs with left-sided cardiac disorders. Objectives: To assess RV and left ventricular (LV) function in dogs with myxomatous mitral valve disease (MMVD) with or without pulmonary hypertension (PH). Animals: One-hundred and fourteen dogs: 28 healthy controls and 86 dogs with MMVD at different stages. Methods: Prospective observational study. Animals were classified as healthy or having MMVD at different stages of severity and according to presence or absence of PH. Twenty-eight morphological, echo-Doppler, and tissue Doppler imaging (TDI) variables were measured and comparison among groups and correlations between LV and RV parameters were studied. Results: No differences were found among groups regarding RV echo-Doppler and TDI variables. Sixteen significant correlations were found between RV TDI and left heart echocardiographic variables. Dogs with PH had significantly higher transmitral E wave peak velocity and higher E/e' ratio of septal (sMV) and lateral (pMV) mitral annulus. These 2 variables were found to predict presence of PH with a sensitivity of 84 and 72%, and a specificity of 71 and 80% at cut-off values of 10 and 9.33 for sMV E/e' and pMV E/e', respectively. Conclusions and clinical importance: No association between variables of RV function and different MMVD stage and severity of PH could be detected. Some relationships were found between echocardiographic variables of right and left ventricular function.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.13940en
dc.identifier.eissn1939-1676en
dc.identifier.issn0891-6640en
dc.identifier.issue3en
dc.identifier.pmid27177623en
dc.identifier.urihttp://hdl.handle.net/10919/92881en
dc.identifier.volume30en
dc.language.isoenen
dc.publisherAmerican College of Veterinary Internal Medicineen
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectCanineen
dc.subjectCardiac diseaseen
dc.subjectEchocardiographyen
dc.subjectright hearten
dc.subjecttissue velocityen
dc.subjectVentricular interdependenceen
dc.titleUtility of Tissue Doppler Imaging in the Echocardiographic Evaluation of Left and Right Ventricular Function in Dogs with Myxomatous Mitral Valve Disease with or without Pulmonary Hypertensionen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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