Diversity in blueberry genotypes and developmental stages enables discrepancy in the bioactive compounds, metabolites, and cytotoxicity

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dc.contributor.authorDas, Protiva Ranien
dc.contributor.authorDarwish, Ahmed G.en
dc.contributor.authorIsmail, Ahmeden
dc.contributor.authorHaikal, Amr M.en
dc.contributor.authorGajjar, Pranavkumaren
dc.contributor.authorBalasubramani, Subramani Paranthamanen
dc.contributor.authorSheikh, Mehboob B.en
dc.contributor.authorTsolova, Violetaen
dc.contributor.authorSoliman, Karam F. A.en
dc.contributor.authorSherif, Sherif M.en
dc.contributor.authorEl-Sharkawy, Islamen
dc.date.accessioned2022-07-01T12:57:05Zen
dc.date.available2022-07-01T12:57:05Zen
dc.date.issued2022-04-16en
dc.description.abstractEight blueberry cultivars at three developmental stages were investigated for metabolite profiling, antioxidant, and anticancer activities. Cultivars- and developmental stages-variations were determined in total phenolic, flavonoid, DPPH, and FRAP antioxidant assays. The anticancer capacity was equal against A549, HepG2, and Caco-2 cancer cells, whereas the inhibition rate was dose-, incubation period-, cultivar-, and developmental stages-dependent. The untargeted metabolite profiling by UPLC-TOF-MS analysis of two contrast cultivars, 'Vernon' and 'Star', throughout the developmental stages revealed 328 metabolites; the majority of them were amino acids, organic acids, and flavonoids. The multivariate statistical analysis identified five metabolites, including quinic acid, methyl succinic acid, chlorogenic acid, oxoadipic acid, and malic acid, with positively higher correlations with all anticancer activities. This comprehensive database of blueberry metabolites along with anticancer activities could be targeted as natural anticancer potentials. This study would be of great value for food, nutraceutical, and pharmaceutical industries as well as plant biotechnologists.en
dc.description.notesThis work was supported by the 1890 Institution Teaching, Research, and Extension Capacity Building Grants (CBG) Program (grant no. 202038821-31086; project accession no. 1021741) from the USDA National Institute of Food and Agriculture.en
dc.description.sponsorship1890 Institution Teaching, Research, and Extension Capacity Building Grants (CBG) Program from the USDA National Institute of Food and Agriculture [202038821-31086, 1021741]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.foodchem.2021.131632en
dc.identifier.eissn1873-7072en
dc.identifier.issn0308-8146en
dc.identifier.other131632en
dc.identifier.pmid34823937en
dc.identifier.urihttp://hdl.handle.net/10919/111083en
dc.identifier.volume374en
dc.language.isoenen
dc.publisherElsevieren
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectBlueberry cultivarsen
dc.subjectBerry developmental stageen
dc.subjectAntioxidanten
dc.subjectAnticanceren
dc.subjectUntargeted metabolomicsen
dc.subjectBiomarker metabolitesen
dc.titleDiversity in blueberry genotypes and developmental stages enables discrepancy in the bioactive compounds, metabolites, and cytotoxicityen
dc.title.serialFood Chemistryen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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