Recruitment and inhibitory action of hippocampal axo-axonic cells during behavior

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dc.contributor.authorDudok, Barnaen
dc.contributor.authorSzoboszlay, Miklosen
dc.contributor.authorPaul, Anirbanen
dc.contributor.authorKlein, Peter M.en
dc.contributor.authorLiao, Zhenruien
dc.contributor.authorHwaun, Ernieen
dc.contributor.authorSzabo, Gergely G.en
dc.contributor.authorGeiller, Tristanen
dc.contributor.authorVancura, Berten
dc.contributor.authorWang, Bor-Shuenen
dc.contributor.authorMcKenzie, Samen
dc.contributor.authorHomidan, Jesslynen
dc.contributor.authorKlaver, Lianne M. F.en
dc.contributor.authorEnglish, Daniel F.en
dc.contributor.authorHuang, Z. Joshen
dc.contributor.authorBuzsaki, Gyorgyen
dc.contributor.authorLosonczy, Attilaen
dc.contributor.authorSoltesz, Ivanen
dc.date.accessioned2022-09-07T12:40:20Zen
dc.date.available2022-09-07T12:40:20Zen
dc.date.issued2021-12-01en
dc.description.abstractThe axon initial segment of hippocampal pyramidal cells is a key subcellular compartment for action potential generation, under GABAergic control by the "chandelier"or axo-axonic cells (AACs). Although AACs are the only cellular source of GABA targeting the initial segment, their in vivo activity patterns and influence over pyramidal cell dynamics are not well understood. We achieved cell-type-specific genetic access to AACs in mice and show that AACs in the hippocampal area CA1 are synchronously activated by episodes of locomotion or whisking during rest. Bidirectional intervention experiments in head-restrained mice performing a random foraging task revealed that AACs inhibit CA1 pyramidal cells, indicating that the effect of GABA on the initial segments in the hippocampus is inhibitory in vivo. Finally, optogenetic inhibition of AACs at specific track locations induced remapping of pyramidal cell place fields. These results demonstrate brain-state -specific dynamics of a critical inhibitory controller of cortical circuits.en
dc.description.notesResearch reported in this publication was supported by the National Institute of Neurological Disorders and Stroke (NINDS) and National Institute of Mental Health (NIMH) of the National Institutes of Health (NIH) under awards NINDSR01NS99457 (to I.S.) ; U19NS104590 (to I.S., A.L., and G.B.) ; K99NS117795 (to B.D.) ; NIMH1R01MH124047, NIMH1R01MH124867, and NINDS1U01NS115530 (to A.L.) ; 5R01MH094705-04 (to Z.J.H.) ; NINDS1F 31NS120783 and NIGMST32GM007367 (to Z.L.) ; NIHT32GM007367 and NIMH1F30MH125628 (to B.V.) ; 5T32NS007280 (to P.M.K. and E.H.) ; and NIH5F32NS096877-03 (to B.S.W.) and by the Kavli Foundation (to A.L.) . A.P. is supported by a NARSAD Young Investigator Fellowship from the Brain & Behavior Research Foundation. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH. We thank the Stanford Neuroscience Gene Vector and Virus Core for providing AAV vector services and Andrew Olson and the Stanford Neuroscience Micro-scopy Service, supported by NIH grant NS069375, for providing microscopy support; we are also grateful to John Perrino and Ruth Yamawaki and the Cell Science Imaging Facility Electron Microscopy Core at Stanford for helpwith electron microscopy. We thank Sylwia Felong, Anna Ortiz, and Sandra Linder for technical and administrative support.en
dc.description.sponsorshipNational Institute of Neurological Disorders and Stroke (NINDS) of the National Institutes of Health (NIH) [NINDSR01NS99457, U19NS104590, K99NS117795, NIMH1R01MH124047, NIMH1R01MH124867, NINDS1U01NS115530, 5R01MH094705-04, NINDS1F 31NS120783, NIGMST32GM007367, NIHT32GM007367, NIMH1F30MH125628, 5T32NS007280, NIH5F32NS096877-03]; National Institute of Mental Health (NIMH) of the National Institutes of Health (NIH) [NINDSR01NS99457, U19NS104590, K99NS117795, NIMH1R01MH124047, NIMH1R01MH124867, NINDS1U01NS115530, 5R01MH094705-04, NINDS1F 31NS120783, NIGMST32GM007367, NIHT32GM007367, NIMH1F30MH125628, 5T32NS007280, NIH5F32NS096877-03]; Kavli Foundation; NARSAD Young Investigator Fellowship from the Brain & Behavior Research Foundation; NIH [NS069375]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.neuron.2021.09.033en
dc.identifier.eissn1097-4199en
dc.identifier.issn0896-6273en
dc.identifier.issue23en
dc.identifier.pmid34648750en
dc.identifier.urihttp://hdl.handle.net/10919/111728en
dc.identifier.volume109en
dc.language.isoenen
dc.publisherCell Pressen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectchandelier cellsen
dc.subjectgabaergic neuronsen
dc.subjectinterneuronal networken
dc.subjectpyramidal cellsen
dc.subjectraten
dc.subjectcortexen
dc.subjectseizuresen
dc.subjectmovementen
dc.subjectdynamicsen
dc.subjectoriginen
dc.titleRecruitment and inhibitory action of hippocampal axo-axonic cells during behavioren
dc.title.serialNeuronen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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