Cumulative Effects of Prior Concussion and Primary Sport Participation on Brain Morphometry in Collegiate Athletes: A Study From the NCAA-DoD CARE Consortium

dc.contributor.authorBrett, Benjamin L.en
dc.contributor.authorBobholz, Samuel A.en
dc.contributor.authorEspana, Lezlie Y.en
dc.contributor.authorHuber, Daniel L.en
dc.contributor.authorMayer, Andrew R.en
dc.contributor.authorHarezlak, Jaroslawen
dc.contributor.authorBroglio, Steven P.en
dc.contributor.authorMcAllister, Thomas W.en
dc.contributor.authorMcCrea, Michael A.en
dc.contributor.authorMeier, Timothy B.en
dc.contributor.authorDiFiori, John P.en
dc.contributor.authorSaykin, Andrew J.en
dc.contributor.authorWu, Yu-Chienen
dc.contributor.authorNencka, Andrew S.en
dc.contributor.authorGiza, Christopher C.en
dc.contributor.authorGoldman, Joshua T.en
dc.contributor.authorMihalik, Jason P.en
dc.contributor.authorBrooks, M. Alisonen
dc.contributor.authorDuma, Stefan M.en
dc.contributor.authorRowson, Stevenen
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessioned2020-11-04T16:21:36Zen
dc.date.available2020-11-04T16:21:36Zen
dc.date.issued2020-07-28en
dc.description.abstractPrior studies have reported long-term differences in brain structure (brain morphometry) as being associated with cumulative concussion and contact sport participation. There is emerging evidence to suggest that similar effects of prior concussion and contact sport participation on brain morphometry may be present in younger cohorts of active athletes. We investigated the relationship between prior concussion and primary sport participation with subcortical and cortical structures in active collegiate contact sport and non-contact sport athletes. Contact sport athletes (CS;N= 190) and matched non-contact sport athletes (NCS;N= 95) completed baseline clinical testing and participated in up to four serial neuroimaging sessions across a 6-months period. Subcortical and cortical structural metrics were derived using FreeSurfer. Linear mixed-effects (LME) models examined the effects of years of primary sport participation and prior concussion (0, 1+) on brain structure and baseline clinical variables. Athletes with prior concussion across both groups reported significantly more baseline concussion and psychological symptoms (allps < 0.05). The relationship between years of primary sport participation and thalamic volume differed between CS and NCS (p= 0.015), driven by a significant inverse association between primary years of participation and thalamic volume in CS (p= 0.007). Additional analyses limited to CS alone showed that the relationship between years of primary sport participation and dorsal striatal volume was moderated by concussion history (p= 0.042). Finally, CS with prior concussion had larger hippocampal volumes than CS without prior concussion (p= 0.015). Years of contact sport exposure and prior concussion(s) are associated with differences in subcortical volumes in young-adult, active collegiate athletes, consistent with prior literature in retired, primarily symptomatic contact sport athletes. Longitudinal follow-up studies in these athletes are needed to determine clinical significance of current findings.en
dc.description.sponsorshipNINDS NIH HHSUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Neurological Disorders & Stroke (NINDS) [R01 NS102225, R21 NS099789, L30 NS113158] Funding Source: Medlineen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fneur.2020.00673en
dc.identifier.issn1664-2295en
dc.identifier.other673en
dc.identifier.pmid32849177en
dc.identifier.urihttp://hdl.handle.net/10919/100787en
dc.identifier.volume11en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectconcussion and sportsen
dc.subjecttraumatic brain injuryen
dc.subjectCARE consortiumen
dc.subjectbrain morphometryen
dc.subjectcontact sport exposureen
dc.subjectgrey matter (GM)en
dc.titleCumulative Effects of Prior Concussion and Primary Sport Participation on Brain Morphometry in Collegiate Athletes: A Study From the NCAA-DoD CARE Consortiumen
dc.title.serialFrontiers In Neurologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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