Modeling the Mechanisms by Which HIV Associated Immunosuppression Influences HPV Persistence at the Oral Mucosa

Simple item page
dc.contributor.authorVerma, Meghnaen
dc.contributor.authorErwin, Samanthaen
dc.contributor.authorAbedi, Vidaen
dc.contributor.authorHontecillas, Raquelen
dc.contributor.authorHoops, Stefanen
dc.contributor.authorLeber, Andrewen
dc.contributor.authorBassaganya-Riera, Josepen
dc.contributor.authorCiupe, Stanca M.en
dc.contributor.departmentMathematicsen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2018-08-01T17:31:51Zen
dc.date.available2018-08-01T17:31:51Zen
dc.date.issued2017-01-06en
dc.description.abstractHuman immunodeficiency virus (HIV)-infected patients are at an increased risk of co-infection with human papilloma virus (HPV), and subsequent malignancies such as oral cancer. To determine the role of HIV-associated immune suppression on HPV persistence and pathogenesis, and to investigate the mechanisms underlying the modulation of HPV infection and oral cancer by HIV, we developed a mathematical model of HIV/HPV co-infection. Our model captures known immunological and molecular features such as impaired HPV-specific effector T helper 1 (Th1) cell responses, and enhanced HPV infection due to HIV. We used the model to determine HPV prognosis in the presence of HIV infection, and identified conditions under which HIV infection alters HPV persistence in the oral mucosa system. The model predicts that conditions leading to HPV persistence during HIV/HPV co-infection are the permissive immune environment created by HIV and molecular interactions between the two viruses. The model also determines when HPV infection continues to persist in the short run in a co-infected patient undergoing antiretroviral therapy. Lastly, the model predicts that, under efficacious antiretroviral treatment, HPV infections will decrease in the long run due to the restoration of CD4+ T cell numbers and protective immune responses.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0168133en
dc.identifier.eissn1932-6203en
dc.identifier.issue1en
dc.identifier.othere0168133en
dc.identifier.pmid28060843en
dc.identifier.urihttp://hdl.handle.net/10919/84461en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleModeling the Mechanisms by Which HIV Associated Immunosuppression Influences HPV Persistence at the Oral Mucosaen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
journal.pone.0168133.pdf
Size:
2.73 MB
Format:
Adobe Portable Document Format
Description:
Download

Collections

Scholarly Works, Fralin Life Sciences Institute