Red Blood Cell Distribution Width, Hematology, and Serum Biochemistry in Dogs with Echocardiographically Estimated Precapillary and Postcapillary Pulmonary Arterial Hypertension

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dc.contributor.authorMazzotta, E.en
dc.contributor.authorGuglielmini, C.en
dc.contributor.authorMenciotti, Giulioen
dc.contributor.authorContiero, B.en
dc.contributor.authorToaldo, M. Baronen
dc.contributor.authorBerlanda, M.en
dc.contributor.authorPoser, H.en
dc.date.accessioned2019-08-07T18:40:01Zen
dc.date.available2019-08-07T18:40:01Zen
dc.date.issued2016-11en
dc.description.abstractBackground: Red blood cell distribution width (RDW) is a quantitative measurement of anisocytosis. RDW has prognostic value in humans with different cardiovascular and systemic disorders, but few studies have investigated this biomarker in dogs. Objectives: To compare the RDW in dogs with precapillary and postcapillary pulmonary hypertension (PH) and a control population of dogs and to correlate RDW with demographic, echocardiographic, and laboratory variables. Animals: One hundred and twenty-seven client-owned dogs including 19 healthy dogs, 82 dogs with myxomatous mitral valve disease (50 dogs without PH and 32 dogs with postcapillary PH), and 26 dogs with precapillary PH. Methods: Prospective study. Dogs were allocated to groups according to clinical and echocardiographic evaluation. RDW and selected laboratory and echocardiographic variables were compared among dog groups. Associations between RDW and demographic, laboratory, and echocardiographic variables were analyzed using correlation and multiple regression analysis. Results: Median RDW in dogs with precapillary PH (13.8%, interquartile range 13.2-14.9%) and postcapillary PH (13.7, 13.2-14.7%) was significantly increased compared to healthy dogs (13.3, 12.3-13.7%; P < .05 for both comparisons), but only dogs with severe PH had significantly increased RDW compared to dogs without PH (P < .05). Peak tricuspid regurgitation pressure gradient was significantly associated with increased RDW (rho = 0.263, P = .007). Serum urea concentration, hematocrit, age, and white blood cell number were significantly associated with RDW in the multivariate analysis. Conclusions and Clinical Importance: Underlying pathophysiologic processes associated with PH instead of severity of PH are likely responsible for increased RDW in dogs with PH.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.14596en
dc.identifier.eissn1939-1676en
dc.identifier.issn0891-6640en
dc.identifier.issue6en
dc.identifier.pmid27747929en
dc.identifier.urihttp://hdl.handle.net/10919/92878en
dc.identifier.volume30en
dc.language.isoenen
dc.publisherAmerican College of Veterinary Internal Medicineen
dc.rightsCreative Commons Attribution-NonCommercial 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/en
dc.subjectAzotemiaen
dc.subjectCanineen
dc.subjectCardiac biomarkeren
dc.subjectCardiovascular diseaseen
dc.subjectEchocardiographyen
dc.titleRed Blood Cell Distribution Width, Hematology, and Serum Biochemistry in Dogs with Echocardiographically Estimated Precapillary and Postcapillary Pulmonary Arterial Hypertensionen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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