Sub-second Dopamine and Serotonin Signaling in Human Striatum during Perceptual Decision-Making
| dc.contributor.author | Bang, Dan | en |
| dc.contributor.author | Kishida, Kenneth T. | en |
| dc.contributor.author | Lohrenz, Terry | en |
| dc.contributor.author | Tatter, Stephen B. | en |
| dc.contributor.author | Fleming, Stephen M. | en |
| dc.contributor.author | Montague, P. Read | en |
| dc.date.accessioned | 2020-10-13T12:51:44Z | en |
| dc.date.available | 2020-10-13T12:51:44Z | en |
| dc.date.issued | 2020-12-09 | en |
| dc.description.abstract | Recent animal research indicates that dopamine and serotonin, neuromodulators traditionally linked to appetitive and aversive processes, are also involved in sensory inference and decisions based on such inference. We tested this hypothesis in humans by monitoring sub-second striatal dopamine and serotonin signaling during a visual motion discrimination task that separates sensory uncertainty from decision difficulty in a factorial design. Caudate nucleus recordings (n = 4) revealed multi-scale encoding: in three participants, serotonin tracked sensory uncertainty, and, in one participant, both dopamine and serotonin tracked deviations from expected trial transitions within our factorial design. Putamen recordings (n = 1) supported a cognitionaction separation between caudate nucleus and putamen—a striatal sub-division unique to primates—with both dopamine and serotonin tracking decision times. These first-of-their-kind observations in the human brain reveal a role for sub-second dopamine and serotonin signaling in non-reward-based aspects of cognition and action. | en |
| dc.description.sponsorship | The Wellcome Centre for Human Neuroimaging is supported by core funding from the Wellcome Trust (203147/Z/16/Z). D.B. is supported by a Sir Henry Wellcome Postdoctoral Fellowship funded by the Wellcome Trust (213630/Z/18/Z). K.T.K. is supported by NIH-NCATS (KL2TR001421), NIH-NIDA (R01-DA048096), NIH-NIMH (R01-MH121099; R01-MH124115), and NIH-NINDS (R01-NS092701). T.L. is supported by NIH-NIMH (R01-MH122948; R01-MH124115) and NIH-NINDS (R01- NS092701). S.M.F. is supported by a Sir Henry Dale Fellowship jointly funded by the Wellcome Trust and the Royal Society (206648/Z/17/Z). P.R.M. is supported by a Principal Research Fellowship funded by the Wellcome Trust (091188/Z/10/Z), NIH-NIMH (R01-MH122948; R01-MH124115), and NIHNINDS (R01-NS092701). | en |
| dc.identifier.doi | https://doi.org/10.1016/j.neuron.2020.09.015 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/100463 | en |
| dc.identifier.volume | 108 | en |
| dc.language.iso | en_US | en |
| dc.publisher | CellPress | en |
| dc.rights | Creative Commons Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.title | Sub-second Dopamine and Serotonin Signaling in Human Striatum during Perceptual Decision-Making | en |
| dc.title.serial | Neuron | en |
| dc.type | Article - Refereed | en |