Natural and Engineered Sex Ratio Distortion in Insects

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dc.contributor.authorCompton, Austinen
dc.contributor.authorTu, Zhijianen
dc.date.accessioned2022-11-21T15:11:17Zen
dc.date.available2022-11-21T15:11:17Zen
dc.date.issued2022-06-15en
dc.description.abstractInsects have evolved highly diverse genetic sex-determination mechanisms and a relatively balanced male to female sex ratio is generally expected. However, selection may shift the optimal sex ratio while meiotic drive and endosymbiont manipulation can result in sex ratio distortion (SRD). Recent advances in sex chromosome genomics and CRISPR/Cas9-mediated genome editing brought significant insights into the molecular regulators of sex determination in an increasing number of insects and provided new ways to engineer SRD. We review these advances and discuss both naturally occurring and engineered SRD in the context of the Anthropocene. We emphasize SRD-mediated biological control of insects to help improve One Health, sustain agriculture, and conserve endangered species.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fevo.2022.884159en
dc.identifier.issn2296-701Xen
dc.identifier.other884159en
dc.identifier.urihttp://hdl.handle.net/10919/112687en
dc.identifier.volume10en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectCRISPRen
dc.subjectCas9en
dc.subjectsex chromosomeen
dc.subjectsex-determinationen
dc.subjectgene driveen
dc.subjectendosymbiont bacteriaen
dc.subjectclimate changeen
dc.subjectsex conversionen
dc.subjectsex-specific lethalityen
dc.titleNatural and Engineered Sex Ratio Distortion in Insectsen
dc.title.serialFrontiers in Ecology and Evolutionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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