A hybrid stochastic model of the budding yeast cell cycle

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dc.contributor.authorAhmadian, Mansoorehen
dc.contributor.authorTyson, John J.en
dc.contributor.authorPeccoud, Jeanen
dc.contributor.authorCao, Yangen
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentComputer Scienceen
dc.date.accessioned2020-05-06T12:35:02Zen
dc.date.available2020-05-06T12:35:02Zen
dc.date.issued2020-03-27en
dc.description.abstractThe growth and division of eukaryotic cells are regulated by complex, multi-scale networks. In this process, the mechanism of controlling cell-cycle progression has to be robust against inherent noise in the system. In this paper, a hybrid stochastic model is developed to study the effects of noise on the control mechanism of the budding yeast cell cycle. The modeling approach leverages, in a single multi-scale model, the advantages of two regimes: (1) the computational efficiency of a deterministic approach, and (2) the accuracy of stochastic simulations. Our results show that this hybrid stochastic model achieves high computational efficiency while generating simulation results that match very well with published experimental measurements.en
dc.description.notesThis work was partially supported by the National Science Foundation under awards CCF-0953590, CCF-1526666, and MCB-1613741. Dr. Peccoud and Dr. Tyson's work was also partially supported by NIH under award GM078989.en
dc.description.sponsorshipNational Science FoundationNational Science Foundation (NSF) [CCF-0953590, CCF-1526666, MCB-1613741]; NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [GM078989]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41540-020-0126-zen
dc.identifier.eissn2056-7189en
dc.identifier.issue1en
dc.identifier.otherUNSP 7en
dc.identifier.pmid32221305en
dc.identifier.urihttp://hdl.handle.net/10919/97986en
dc.identifier.volume6en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleA hybrid stochastic model of the budding yeast cell cycleen
dc.title.serialnpj Systems Biology and Applicationsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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