Distinguishing the Unique Neuropathological Profile of Blast Polytrauma

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dc.contributor.authorHubbard, W. Braden
dc.contributor.authorGreenberg, Shaylenen
dc.contributor.authorNorris, Carlyen
dc.contributor.authorEck, Josephen
dc.contributor.authorLavik, Erinen
dc.contributor.authorVandeVord, Pamela J.en
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessioned2017-09-18T09:33:29Zen
dc.date.available2017-09-18T09:33:29Zen
dc.date.issued2017-03-23en
dc.date.updated2017-09-18T09:33:29Zen
dc.description.abstractTraumatic brain injury sustained after blast exposure (blast-induced TBI) has recently been documented as a growing issue for military personnel. Incidence of injury to organs such as the lungs has decreased, though current epidemiology still causes a great public health burden. In addition, unprotected civilians sustain primary blast lung injury (PBLI) at alarming rates. Often, mild-to-moderate cases of PBLI are survivable with medical intervention, which creates a growing population of survivors of blast-induced polytrauma (BPT) with symptoms from blast-induced mild TBI (mTBI). Currently, there is a lack of preclinical models simulating BPT, which is crucial to identifying unique injury mechanisms of BPT and its management. To meet this need, our group characterized a rodent model of BPT and compared results to a blast-induced mTBI model. Open field (OF) performance trials were performed on rodents at 7 days after injury. Immunohistochemistry was performed to evaluate cellular outcome at day seven following BPT. Levels of reactive astrocytes (GFAP), apoptosis (cleaved caspase-3 expression), and vascular damage (SMI-71) were significantly elevated in BPT compared to blast-induced mTBI. Downstream markers of hypoxia (HIF-1α and VEGF) were higher only after BPT. This study highlights the need for unique therapeutics and prehospital management when handling BPT.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationW. Brad Hubbard, Shaylen Greenberg, Carly Norris, Joseph Eck, Erin Lavik, and Pamela VandeVord, “Distinguishing the Unique Neuropathological Profile of Blast Polytrauma,” Oxidative Medicine and Cellular Longevity, vol. 2017, Article ID 5175249, 11 pages, 2017. doi:10.1155/2017/5175249en
dc.identifier.doihttps://doi.org/10.1155/2017/5175249en
dc.identifier.urihttp://hdl.handle.net/10919/78920en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2017 W. Brad Hubbard et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleDistinguishing the Unique Neuropathological Profile of Blast Polytraumaen
dc.title.serialOxidative Medicine and Cellular Longevityen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Journal Articles, Hindawi Press
Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Biomedical Engineering and Mechanics