Canine Butterfly Glioblastomas: a Neuroradiological Review

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dc.contributor.authorRossmeisl, John H. Jr.en
dc.contributor.authorClapp, Kembaen
dc.contributor.authorPancotto, Theresa E.en
dc.contributor.authorEmch, Samanthaen
dc.contributor.authorRobertson, John L.en
dc.contributor.authorDebinski, Waldemaren
dc.date.accessioned2019-01-31T16:06:37Zen
dc.date.available2019-01-31T16:06:37Zen
dc.date.issued2016-05-19en
dc.description.abstractIn humans, high-grade gliomas may infiltrate across the corpus callosum resulting in bihemispheric lesions that may have symmetrical, winged-like appearances. This particular tumor manifestation has been coined a “butterfly” glioma (BG). While canine and human gliomas share many neuroradiological and pathological features, the BG morphology has not been previously reported in dogs. Here, we describe the magnetic resonance imaging (MRI) characteristics of BG in three dogs and review the potential differential diagnoses based on neuroimaging findings. All dogs presented for generalized seizures and interictal neurological deficits referable to multifocal or diffuse forebrain disease. MRI examinations revealed asymmetrical (2/3) or symmetrical (1/3), bihemispheric intra-axial mass lesions that predominantly affected the frontoparietal lobes that were associated with extensive perilesional edema, and involvement of the corpus callosum. The masses displayed heterogeneous T1, T2, and fluid-attenuated inversion recovery signal intensities, variable contrast enhancement (2/3), and mass effect. All tumors demonstrated classical histopathological features of glioblastoma multiforme (GBM), including glial cell pseudopalisading, serpentine necrosis, microvascular proliferation as well as invasion of the corpus callosum by neoplastic astrocytes. Although rare, GBM should be considered a differential diagnosis in dogs with an MRI evidence of asymmetric or symmetric bilateral, intra-axial cerebral mass lesions with signal characteristics compatible with glioma.en
dc.description.sponsorshipImmunohistochemical reagents and studies were funded in part by: CA139099/CA/NCI NIH HHS and Brain Tumor Center of Excellence at Wake Forest School of Medicine.en
dc.description.versionPublished versionen
dc.format.extent8 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationRossmeisl JH, Clapp K, Pancotto TE, Emch S, Robertson JL and Debinski W (2016) Canine Butterfly Glioblastomas: A Neuroradiological Review. Front. Vet. Sci. 3:40. doi: 10.3389/fvets.2016.00040en
dc.identifier.doihttps://doi.org/10.3389/fvets.2016.00040en
dc.identifier.urihttp://hdl.handle.net/10919/87095en
dc.identifier.volume3en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectastrocytomaen
dc.subjectbrain tumoren
dc.subjectcanineen
dc.subjectglioblastomaen
dc.subjectmagnetic resonance imagingen
dc.titleCanine Butterfly Glioblastomas: a Neuroradiological Reviewen
dc.title.serialFrontiers in Veterinary Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Small Animal Clinical Sciences
Destination Area: Adaptive Brain and Behavior (ABB)