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Comparison of Whole-Genome Sequences of Legionella pneumophila in Tap Water and in Clinical Strains, Flint, Michigan, USA, 2016

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dc.contributor.authorGarner, Emilyen
dc.contributor.authorBrown, Connor L.en
dc.contributor.authorSchwake, David Ottoen
dc.contributor.authorRhoads, William J.en
dc.contributor.authorArango-Argoty, Gustavoen
dc.contributor.authorZhang, Liqingen
dc.contributor.authorJospin, Guillaumeen
dc.contributor.authorCoil, David A.en
dc.contributor.authorEisen, Jonathan A.en
dc.contributor.authorEdwards, Marc A.en
dc.contributor.authorPruden, Amyen
dc.contributor.departmentCivil and Environmental Engineeringen
dc.date.accessioned2019-10-18T13:07:14Zen
dc.date.available2019-10-18T13:07:14Zen
dc.date.issued2019-11en
dc.description.abstractDuring the water crisis in Flint, Michigan, USA (2014–2015), 2 outbreaks of Legionnaires’ disease occurred in Genesee County, Michigan. We compared whole-genome sequences of 10 clinical Legionella pneumophila isolates submitted to a laboratory in Genesee County during the second outbreak with 103 water isolates collected the following year. We documented a genetically diverse range of L. pneumophila strains across clinical and water isolates. Isolates belonging to 1 clade (3 clinical isolates, 3 water isolates from a Flint hospital, 1 water isolate from a Flint residence, and the reference Paris strain) had a high degree of similarity (2–1,062 single-nucleotide polymorphisms), all L. pneumophila sequence type 1, serogroup 1. Serogroup 6 isolates belonging to sequence type 2518 were widespread in Flint hospital water samples but bore no resemblance to available clinical isolates. L. pneumophila strains in Flint tap water after the outbreaks were diverse and similar to some disease-causing strains.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3201/eid2511.181032en
dc.identifier.issue11en
dc.identifier.urihttp://hdl.handle.net/10919/94633en
dc.identifier.volume25en
dc.language.isoenen
dc.publisherCenters for Disease Control and Preventionen
dc.rightsCreative Commons CC0 1.0 Universal Public Domain Dedicationen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/en
dc.titleComparison of Whole-Genome Sequences of Legionella pneumophila in Tap Water and in Clinical Strains, Flint, Michigan, USA, 2016en
dc.title.serialEmerging Infectious Diseasesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Civil and Environmental Engineering
Destination Area: Global Systems Science (GSS)