Phytochemical Isoliquiritigenin Inhibits Angiogenesis Ex Vivo and Corneal Neovascularization in Mice
| dc.contributor.author | Wang, Lingling | en |
| dc.contributor.author | He, Wenxiao | en |
| dc.contributor.author | Qu, Huihua | en |
| dc.contributor.author | Jia, Changkai | en |
| dc.contributor.author | Wang, Yao | en |
| dc.contributor.author | Wang, Yiqiang | en |
| dc.contributor.author | Liu, Dongmin | en |
| dc.date.accessioned | 2021-04-26T13:58:31Z | en |
| dc.date.available | 2021-04-26T13:58:31Z | en |
| dc.date.issued | 2014-11-21 | en |
| dc.description.abstract | Neovascularization is often involved in many diseases and there is no effective treatment for this pathological process. In searching for potential therapies for neovascularization, we screened nineteen pre-selected small molecules isolated from herbal extracts for their possible anti-angiogenic effect in vitro and in vivo. We found that isoliquiritigenin, a chalconoid compound isolated from Chinese herb medicine licorice, potently inhibited vascular endothelial cell (EC) proliferation, migration, tube -like structure formation ex vivo. Western blot analysis shows that exposure of ECs to isoliquiritigenin inhibited extracellular signal-regulated kinase 1/2 (ERK1/2) phosphorylation. In Matrigel plug assay, isoliquiritigenin effectively blocked fibroblast growth factor-induced in vivo angiogenesis in mice. Consistently, topical application of isoliquiritigenin significantly inhibited chemical injury-induced corneal neovascularization in mice. Collectively, these results suggest that isoliquiritigenin may be a low-cost and effective natural agent to treat angiogenesis-dependent diseases. | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.doi | http://dx.doi.org/10.4172/2327-5162.1000176 | en |
| dc.identifier.issue | 4 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/103123 | en |
| dc.identifier.volume | 3 | en |
| dc.language.iso | en | en |
| dc.publisher | Hilaris | en |
| dc.rights | Attribution 4.0 International | en |
| dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
| dc.subject | Isoliquiritigenin | en |
| dc.subject | Vascular endothelial cell | en |
| dc.subject | Proliferation | en |
| dc.subject | Migration | en |
| dc.subject | Angiogenesis | en |
| dc.subject | Neovascularization | en |
| dc.title | Phytochemical Isoliquiritigenin Inhibits Angiogenesis Ex Vivo and Corneal Neovascularization in Mice | en |
| dc.title.serial | Alternative & Integrative Medicine | en |
| dc.type | Article - Refereed | en |
| dc.type.dcmitype | Text | en |