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Diverse Lifestyles and Strategies of Plant Pathogenesis Encoded in the Genomes of Eighteen Dothideomycetes Fungi

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dc.contributorVirginia Techen
dc.contributor.authorOhm, Robin A.en
dc.contributor.authorFeau, Nicolasen
dc.contributor.authorHenrissat, Bernarden
dc.contributor.authorSchoch, Conrad L.en
dc.contributor.authorHorwitz, Benjamin A.en
dc.contributor.authorBarry, Kerrie W.en
dc.contributor.authorCondon, Bradford J.en
dc.contributor.authorCopeland, Alex C.en
dc.contributor.authorDhillon, Brahamen
dc.contributor.authorGlaser, Fabianen
dc.contributor.authorHesse, Cedar N.en
dc.contributor.authorKosti, Iditen
dc.contributor.authorLaButti, Kurten
dc.contributor.authorLindquist, Erika A.en
dc.contributor.authorLucas, Susanen
dc.contributor.authorSalamov, Asaf A.en
dc.contributor.authorBradshaw, Rosie E.en
dc.contributor.authorCiuffetti, Lyndaen
dc.contributor.authorHamelin, Richard C.en
dc.contributor.authorKema, Gert H. J.en
dc.contributor.authorLawrence, Christopher B.en
dc.contributor.authorScott, James A.en
dc.contributor.authorSpatafora, Joseph W.en
dc.contributor.authorTurgeon, B. Gillianen
dc.contributor.authorde Whit, Pierre J. G. M.en
dc.contributor.authorZhong, Shaobinen
dc.contributor.authorGoodwin, Stephen B.en
dc.contributor.authorGrigoriev, Igor V.en
dc.date.accessed2014-05-06en
dc.date.accessioned2014-06-17T20:12:10Zen
dc.date.available2014-06-17T20:12:10Zen
dc.date.issued2012-12-06en
dc.description.abstractThe class Dothideomycetes is one of the largest groups of fungi with a high level of ecological diversity including many plant pathogens infecting a broad range of hosts. Here, we compare genome features of 18 members of this class, including 6 necrotrophs, 9 (hemi)biotrophs and 3 saprotrophs, to analyze genome structure, evolution, and the diverse strategies of pathogenesis. The Dothideomycetes most likely evolved from a common ancestor more than 280 million years ago. The 18 genome sequences differ dramatically in size due to variation in repetitive content, but show much less variation in number of (core) genes. Gene order appears to have been rearranged mostly within chromosomal boundaries by multiple inversions, in extant genomes frequently demarcated by adjacent simple repeats. Several Dothideomycetes contain one or more gene-poor, transposable element (TE)-rich putatively dispensable chromosomes of unknown function. The 18 Dothideomycetes offer an extensive catalogue of genes involved in cellulose degradation, proteolysis, secondary metabolism, and cysteine-rich small secreted proteins. Ancestors of the two major orders of plant pathogens in the Dothideomycetes, the Capnodiales and Pleosporales, may have had different modes of pathogenesis, with the former having fewer of these genes than the latter. Many of these genes are enriched in proximity to transposable elements, suggesting faster evolution because of the effects of repeat induced point (RIP) mutations. A syntenic block of genes, including oxidoreductases, is conserved in most Dothideomycetes and upregulated during infection in L. maculans, suggesting a possible function in response to oxidative stress.en
dc.description.sponsorshipThe work done by U.S. Department of Energy Joint Genome Institute is supported by the Office of Science of the U.S. Department of Energy under contract number DE-AC02-05CH11231. This work was supported in part by USDA-ARS CRIS project 3602-22000-015-00D. CLS acknowledges support from the Intramural Research Program of the NIH, National Library of Medicine. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.identifier.citationOhm RA, Feau N, Henrissat B, Schoch CL, Horwitz BA, et al. (2012) Diverse Lifestyles and Strategies of Plant Pathogenesis Encoded in the Genomes of Eighteen Dothideomycetes Fungi. PLoS Pathog 8(12): e1003037en
dc.identifier.doihttps://doi.org/10.1371/journal.ppat.1003037en
dc.identifier.issn1553-7374en
dc.identifier.urihttp://hdl.handle.net/10919/49010en
dc.identifier.urlhttp://www.plospathogens.org/article/info%3Adoi%2F10.1371%2Fjournal.ppat.1003037en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectChromosomesen
dc.subjectFungalgenomicsen
dc.subjectFungien
dc.subjectGenome evolutionen
dc.subjectGenomic databasesen
dc.subjectPlant fungal pathogensen
dc.subjectPlant genomicsen
dc.subjectPlant pathogensen
dc.titleDiverse Lifestyles and Strategies of Plant Pathogenesis Encoded in the Genomes of Eighteen Dothideomycetes Fungien
dc.title.serialPLoS Pathogensen
dc.typeArticle - Refereeden

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