Rapidly evolving changes and gene loss associated with host switching in Corynebacterium pseudotuberculosis

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dc.contributor.authorCanario Viana, Marcus Viniciusen
dc.contributor.authorSahm, Arneen
dc.contributor.authorGoes Neto, Aristotelesen
dc.contributor.authorPereira Figueiredo, Henrique Cesaren
dc.contributor.authorWattam, Alice Rebeccaen
dc.contributor.authorAzevedo, Vascoen
dc.date.accessioned2019-05-31T14:08:24Zen
dc.date.available2019-05-31T14:08:24Zen
dc.date.issued2018-11-12en
dc.description.abstractPhylogenomics and genome scale positive selection analyses were performed on 29 Corynebacterium pseudotuberculosis genomes that were isolated from different hosts, including representatives of the Ovis and Equi biovars. A total of 27 genes were identified as undergoing adaptive changes. An analysis of the clades within this species and these biovars, the genes specific to each branch, and the genes responding to selective pressure show clear differences, indicating that adaptation and specialization is occurring in different clades. These changes are often correlated with the isolation host but could indicate responses to some undetermined factor in the respective niches. The fact that some of these more-rapidly evolving genes have homology to known virulence factors, antimicrobial resistance genes and drug targets shows that this type of analysis could be used to identify novel targets, and that these could be used as a way to control this pathogen.en
dc.description.notesThis work was supported by: Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (www.capes.gov.br), Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (cnpq.br), and Pro-Reitoria de Pesquisa e Extensao of Universidade Federal de Minas Gerais (www.ufmg.br/prpq).A.R.Wattam was supported in part by federal funds from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (www.nih.gov).The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.en
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior; Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (cnpq.br); Pro-Reitoria de Pesquisa e Extensao of Universidade Federal de Minas Gerais; National Institute of Allergy and Infectious Diseases, National Institutes of Healthen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0207304en
dc.identifier.eissn1932-6203en
dc.identifier.issue11en
dc.identifier.othere0207304en
dc.identifier.pmid30419061en
dc.identifier.urihttp://hdl.handle.net/10919/89658en
dc.identifier.volume13en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleRapidly evolving changes and gene loss associated with host switching in Corynebacterium pseudotuberculosisen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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