Influenza Virus Infectivity Is Retained in Aerosols and Droplets Independent of Relative Humidity

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dc.contributor.authorKormuth, Karen A.en
dc.contributor.authorLin, Kaisenen
dc.contributor.authorPrussin, Aaron J. IIen
dc.contributor.authorVejerano, Eric P.en
dc.contributor.authorTiwari, Andrea J.en
dc.contributor.authorCox, Steve S.en
dc.contributor.authorMyerburg, Michael M.en
dc.contributor.authorLakdawala, Seema S.en
dc.contributor.authorMarr, Linsey C.en
dc.contributor.departmentCivil and Environmental Engineeringen
dc.date.accessioned2018-11-01T15:54:19Zen
dc.date.available2018-11-01T15:54:19Zen
dc.date.issued2018-06-07en
dc.description.abstractPandemic and seasonal influenza viruses can be transmitted through aerosols and droplets, in which viruses must remain stable and infectious across a wide range of environmental conditions. Using humidity-controlled chambers, we studied the impact of relative humidity on the stability of 2009 pandemic influenza A(H1N1) virus in suspended aerosols and stationary droplets. Contrary to the prevailing paradigm that humidity modulates the stability of respiratory viruses in aerosols, we found that viruses supplemented with material from the apical surface of differentiated primary human airway epithelial cells remained equally infectious for 1 hour at all relative humidities tested. This sustained infectivity was observed in both fine aerosols and stationary droplets. Our data suggest, for the first time, that influenza viruses remain highly stable and infectious in aerosols across a wide range of relative humidities. These results have significant implications for understanding the mechanisms of transmission of influenza and its seasonality.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1093/infdis/jiy221en
dc.identifier.issue5en
dc.identifier.urihttp://hdl.handle.net/10919/85617en
dc.identifier.volume218en
dc.language.isoenen
dc.publisherOxford University Pressen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectInfluenza virusen
dc.subjectRelative humidityen
dc.subjectrotating drumen
dc.subjectAerosolen
dc.subjectMucusen
dc.subjectRespiratory airway cellsen
dc.subjectTransmissionen
dc.titleInfluenza Virus Infectivity Is Retained in Aerosols and Droplets Independent of Relative Humidityen
dc.title.serialJournal of Infectious Diseasesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Civil and Environmental Engineering
Destination Area: Global Systems Science (GSS)