Effects of internal electrode cooling on irreversible electroporation using a perfused organ model
dc.contributor.author | O’Brien, T. J. | en |
dc.contributor.author | Bonakdar, Mohammad | en |
dc.contributor.author | Bhonsle, Suyashree P. | en |
dc.contributor.author | Neal, Robert E. | en |
dc.contributor.author | Aardema, C.H. | en |
dc.contributor.author | Robertson, John L. | en |
dc.contributor.author | Goldberg, S.N. | en |
dc.contributor.author | Davalos, Rafael V. | en |
dc.date.accessioned | 2019-04-09T13:14:35Z | en |
dc.date.available | 2019-04-09T13:14:35Z | en |
dc.date.issued | 2018-05-28 | en |
dc.description.abstract | Purpose: This study evaluates the effects of active electrode cooling, via internal fluid circulation, on the irreversible electroporation (IRE) lesion, deployed electric current and temperature changes using a perfused porcine liver model. Materials and methods: A bipolar electrode delivered IRE electric pulses with or without activation of internal cooling to nine porcine mechanically perfused livers. Pulse schemes included a constant voltage, and a preconditioned delivery combined with an arc-mitigation algorithm. After treatment, organs were dissected, and treatment zones were stained using triphenyl-tetrazolium chloride (TTC) to demonstrate viability. Results: Thirty-nine treatments were performed with an internally cooled applicator and 21 with a non-cooled applicator. For the constant voltage scenario, the average final electrical current measured was 26.37 and 29.20 A for the cooled and uncooled electrodes respectively (p≤.001). The average final temperature measured was 33.01 and 42.43 °C for the cooled and uncooled electrodes respectively (p≤.0001). The average measured ablations (fixed lesion) were 3.88-by-2.08 cm and 3.86-by-2.12 cm for the cooled and uncooled electrode respectively (p≤.2495, p≤.7507). Similarly, the preconditioned/arc-mitigation scenario yielded an average final electrical current measurement of a 41.07 and 47.20 A for the cooled and uncooled electrodes respectively (p≤.0001). The average final temperature measured was 34.93 and 44.90 °C for the cooled and uncooled electrodes respectively (p≤.0001). The average measured ablations (fixed lesion) were 3.67-by-2.27 cm and 3.58-by-2.09 cm for the cooled and uncooled applicators ((p≤.7906; p≤.5595)). Conclusions: The internally-cooled bipolar applicator offers advantages that could improve clinical outcomes. Thermally mitigating internal perfusion technology reduced tissue temperatures and electric current while maintaining similar lesion sizes. | en |
dc.description.notes | This study was supported in part by AngioDynamics Inc. and the Pancreatic Cancer Action Network Translational Research Grant [PanCAN 16–65-IANN]. The authors would also like to acknowledge support from the Institute for Critical Technology and Applied Science (ICTAS) and its Center for Engineered Health (CEH) of Virginia Tech. | en |
dc.format.mimetype | application/pdf | en |
dc.identifier.doi | https://doi.org/10.1080/02656736.2018.1473893 | en |
dc.identifier.issn | 0265-6736 | en |
dc.identifier.issue | 1 | en |
dc.identifier.pmid | 29806513 | en |
dc.identifier.uri | http://hdl.handle.net/10919/88874 | en |
dc.identifier.volume | 35 | en |
dc.language.iso | en_US | en |
dc.publisher | Taylor and Francis Ltd | en |
dc.rights | Creative Commons Attribution 4.0 International | en |
dc.rights.uri | http://creativecommons.org/licenses/by/4.0/ | en |
dc.subject | arc mitigation | en |
dc.subject | current | en |
dc.subject | Irreversible electroporation | en |
dc.subject | perfused organ model | en |
dc.subject | Temperature | en |
dc.subject | thermal damage | en |
dc.subject | thermal mitigation | en |
dc.title | Effects of internal electrode cooling on irreversible electroporation using a perfused organ model | en |
dc.title.serial | International Journal of Hyperthermia | en |
dc.type | Article - Refereed | en |
dc.type.dcmitype | Text | en |
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