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Mycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010-2012

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dc.contributor.authorLande, Leahen
dc.contributor.authorAlexander, David C.en
dc.contributor.authorWallace, Richard J. Jr.en
dc.contributor.authorKwait, Rebeccaen
dc.contributor.authorIakhiaeva, Elenaen
dc.contributor.authorWilliams, Myra D.en
dc.contributor.authorCameron, Andrew D. S.en
dc.contributor.authorOlshefsky, Stephenen
dc.contributor.authorDevon, Roniten
dc.contributor.authorVasireddy, Ravikiranen
dc.contributor.authorPeterson, Donald D.en
dc.contributor.authorFalkinham, Joseph O. IIIen
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2019-08-19T18:09:59Zen
dc.date.available2019-08-19T18:09:59Zen
dc.date.issued2019-03en
dc.description.abstractAttention to environmental sources of Mycobacterium avium complex (MAC) infection is a vital component of disease prevention and control. We investigated MAC colonization of household plumbing in suburban Philadelphia, Pennsylvania, USA. We used variable-number tandemrepeat genotyping and whole-genome sequencing with core genome single-nucleotide variant analysis to compare M. avium from household plumbing biofilms with M. avium isolates from patient respiratory specimens. M. avium was recovered from 30 (81.1%) of 37 households, including 19 (90.5%) of 21 M. avium patient households. For 11 (52.4%) of 21 patients with M. avium disease, isolates recovered from their respiratory and household samples were of the same genotype. Within the same community, 18 (85.7%) of 21 M. avium respiratory isolates genotypically matched household plumbing isolates. Six predominant genotypes were recovered across multiple households and respiratory specimens. M. avium colonizing municipal water and household plumbing may be a substantial source of MAC pulmonary infection.en
dc.description.notesFinancial support for the Mycobacteria/Nocardia Research Laboratory was provided by in-house funding, patient donations, and the Amon G. Carter Foundation. Financial support for the household sampling was provided in part by the Lankenau Medical Center Women's Board. Financial support for WGS was provided by the Saskatchewan Health Research Foundation, grant nos. 2867 and 3378.en
dc.description.sponsorshipAmon G. Carter Foundation; Lankenau Medical Center Women's Board; Saskatchewan Health Research Foundation [2867, 3378]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3201/eid2503.180336en
dc.identifier.eissn1080-6059en
dc.identifier.issn1080-6040en
dc.identifier.issue3en
dc.identifier.pmid30789130en
dc.identifier.urihttp://hdl.handle.net/10919/93182en
dc.identifier.volume25en
dc.language.isoenen
dc.rightsCreative Commons CC0 1.0 Universal Public Domain Dedicationen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/en
dc.subjectlung-diseaseen
dc.subjectnontuberculous mycobacteriaen
dc.subjectsubsp hominissuisen
dc.subjectcomplexen
dc.subjectintracellulareen
dc.subjectepidemiologyen
dc.subjectinfectionen
dc.subjectvntren
dc.subjectestablishmenten
dc.subjectemergenceen
dc.titleMycobacterium avium in Community and Household Water, Suburban Philadelphia, Pennsylvania, USA, 2010-2012en
dc.title.serialEmerging Infectious Diseasesen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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