Collagen XIX is required for pheromone recognition and glutamatergic synapse formation in mouse accessory olfactory bulb

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dc.contributor.authorAmos, Chaseen
dc.contributor.authorFox, Michael A.en
dc.contributor.authorSu, Jianminen
dc.date.accessioned2023-09-07T19:05:04Zen
dc.date.available2023-09-07T19:05:04Zen
dc.date.issued2023-04en
dc.description.abstractIn mammals, the accessory olfactory bulb (AOB) receives input from vomeronasal sensory neurons (VSN) which detect pheromones, chemical cues released by animals to regulate the physiology or behaviors of other animals of the same species. Cytoarchitecturally, cells within the AOB are segregated into a glomerular layer (GL), mitral cell layer (MCL), and granule cell layer (GCL). While the cells and circuitry of these layers has been well studied, the molecular mechanism underlying the assembly of such circuitry in the mouse AOB remains unclear. With the goal of identifying synaptogenic mechanisms in AOB, our attention was drawn to Collagen XIX, a non-fibrillar collagen generated by neurons in the mammalian telencephalon that has previously been shown to regulate the assembly of synapses. Here, we used both a targeted mouse mutant that lacks Collagen XIX globally and a conditional allele allowing for cell-specific deletion of this collagen to test if the loss of Collagen XIX causes impaired synaptogenesis in the mouse AOB. These analyses not only revealed defects in excitatory synapse distribution in these Collagen XIX-deficient mutants, but also showed that these mutant mice exhibit altered behavioral responses to pheromones. Although this collagen has been demonstrated to play synaptogenic roles in the telencephalon, those roles are at perisomatic inhibitory synapses, results here are the first to demonstrate the function of this unconventional collagen in glutamatergic synapse formation.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fncel.2023.1157577en
dc.identifier.eissn1662-5102en
dc.identifier.other1157577en
dc.identifier.pmid37091919en
dc.identifier.urihttp://hdl.handle.net/10919/116242en
dc.identifier.volume17en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectaccessory olfactory bulben
dc.subjectCollagen XIXen
dc.subjectglutamatergic synapseen
dc.subjectsynaptogenesisen
dc.subjectpheromone recognitionen
dc.subjectdevelopmenten
dc.titleCollagen XIX is required for pheromone recognition and glutamatergic synapse formation in mouse accessory olfactory bulben
dc.title.serialFrontiers in Cellular Neuroscienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Fralin Biomedical Research Institute at VTC
Scholarly Works, Biological Sciences
Scholarly Works, School of Neuroscience
Scholarly Works, Virginia Tech Carilion School of Medicine (VTCSOM)