Metabolic Engineering of Yeast to Produce Fatty Acid-derived Biofuels: Bottlenecks and Solutions

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dc.contributorVirginia Tech. Department of Biological Systems Engineeringen
dc.contributor.authorSheng, Jiayuanen
dc.contributor.authorFeng, Xueyangen
dc.contributor.departmentBiological Systems Engineeringen
dc.contributor.editorMukhopadhyay, Aindrilaen
dc.date.accessed2016-02-12en
dc.date.accessioned2016-02-16T08:03:28Zen
dc.date.available2016-02-16T08:03:28Zen
dc.date.issued2015-06-08en
dc.description.abstractFatty acid-derived biofuels can be a better solution than bioethanol to replace petroleum fuel, since they have similar energy content and combustion properties as current transportation fuels. The environmentally friendly microbial fermentation process has been used to synthesize advanced biofuels from renewable feedstock. Due to their robustness as well as the high tolerance to fermentation inhibitors and phage contamination, yeast strains such as Saccharomyces cerevisiae and Yarrowia lipolytica have attracted tremendous attention in recent studies regarding the production of fatty acid-derived biofuels, including fatty acids, fatty acid ethyl esters, fatty alcohols, and fatty alkanes. However, the native yeast strains cannot produce fatty acids and fatty acid-derived biofuels in large quantities. To this end, we have summarized recent publications in this review on metabolic engineering of yeast strains to improve the production of fatty acid-derived biofuels, identified the bottlenecks that limit the productivity of biofuels, and categorized the appropriate approaches to overcome these obstacles.en
dc.description.sponsorshipVirginia Tech. Start-up fund - #175323en
dc.description.sponsorshipVirginia Tech. Open Access Subvention Funden
dc.format.extent11 p.en
dc.format.mimetypeapplication/pdfen
dc.identifier.citationSheng J. and Feng X. (2015). Metabolic engineering of yeast to produce fatty acid-derived biofuels: bottlenecks and solutions. Front. Microbiol. 6:554. doi: 10.3389/fmicb.2015.00554en
dc.identifier.doihttps://doi.org/10.3389/fmicb.2015.00554en
dc.identifier.issn1664-302Xen
dc.identifier.urihttp://hdl.handle.net/10919/64816en
dc.identifier.urlhttp://journal.frontiersin.org/article/10.3389/fmicb.2015.00554/fullen
dc.identifier.volume6en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderSheng, Jiayuanen
dc.rights.holderFeng, Xueyanen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectFatty acid biosynthesisen
dc.subjectS. cerevisiaeen
dc.subjectY. lipolyticaen
dc.subjectAcetyl-CoAen
dc.subjectMetabolic regulationen
dc.titleMetabolic Engineering of Yeast to Produce Fatty Acid-derived Biofuels: Bottlenecks and Solutionsen
dc.title.serialFrontiers in Microbiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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