Experimental parasite community perturbation reveals associations between Sin Nombre virus and gastrointestinal nematodes in a rodent reservoir host

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dc.contributor.authorSweeny, Amy R.en
dc.contributor.authorThomason, Courtney A.en
dc.contributor.authorCarbajal, Edwin A.en
dc.contributor.authorHansen, Christina B.en
dc.contributor.authorGraham, Andrea L.en
dc.contributor.authorPedersen, Amy B.en
dc.contributor.departmentBiological Sciencesen
dc.date.accessioned2021-02-11T14:16:04Zen
dc.date.available2021-02-11T14:16:04Zen
dc.date.issued2020-12-23en
dc.description.abstractIndividuals are often co-infected with several parasite species, yet measuring within-host interactions remains difficult in the wild. Consequently, the impacts of such interactions on host fitness and epidemiology are often unknown. We used anthelmintic drugs to experimentally reduce nematode infection and measured the effects on both nematodes and the important zoonosis Sin Nombre virus (SNV) in its primary reservoir (Peromyscus spp.). Treatment significantly reduced nematode infection, but increased SNV seroprevalence. Furthermore, mice that were co-infected with both nematodes and SNV were in better condition and survived up to four times longer than uninfected or singly infected mice. These results highlight the importance of investigating multiple parasites for understanding interindividual variation and epidemiological dynamics in reservoir populations with zoonotic transmission potential.en
dc.description.notesThis project was funded by a Centre for Infection, Immunology and Evolution Advanced Fellowship (Wellcome Trust U.K. Strategic grant, 095831) and University of Edinburgh Chancellors Fellowship to A.B.P, a DARPA grant (no. 68255-LS-DRP) to A.L.G., a Sigma Xi Grants-in-Aid of Research award (G20101015154773), an American Society of Mammalogists Grants-in-Aid of Research award, the Margaret Walton Scholarship for Mountain Lake Biological Station, and a Texas Tech University Association of Biologists grant to C.A.T., and NSF Research Experiences for Undergraduates grant nos DBI-1005104 and DBI-0453380. A.R.S. and E.A.C.'s undergraduate work was funded by the Princeton EEB Department, the Princeton Environmental Institute Grand Challenges Fund (A.R.S.) and the Mellon Mays Undergraduate Fellowship (E.A.C.).en
dc.description.sponsorshipCentre for Infection, Immunology and Evolution Advanced Fellowship (Wellcome Trust U.K.) [095831]; University of Edinburgh Chancellors Fellowship; DARPAUnited States Department of DefenseDefense Advanced Research Projects Agency (DARPA) [68255-LS-DRP]; Sigma Xi [G20101015154773]; American Society of Mammalogists; Margaret Walton Scholarship for Mountain Lake Biological Station; Texas Tech University Association of Biologists grant; NSF Research Experiences for UndergraduatesNational Science Foundation (NSF) [DBI-1005104, DBI-0453380]; Princeton EEB Department; Princeton Environmental Institute Grand Challenges Fund; Mellon Mays Undergraduate Fellowshipen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1098/rsbl.2020.0604en
dc.identifier.eissn1744-957Xen
dc.identifier.issn1744-9561en
dc.identifier.issue12en
dc.identifier.other20200604en
dc.identifier.pmid33353521en
dc.identifier.urihttp://hdl.handle.net/10919/102343en
dc.identifier.volume16en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectSin Nombre virusen
dc.subjectgastrointestinal nematodesen
dc.subjectdisease controlen
dc.subjectreservoir hosten
dc.subjectco-infectionen
dc.titleExperimental parasite community perturbation reveals associations between Sin Nombre virus and gastrointestinal nematodes in a rodent reservoir hosten
dc.title.serialBiology Lettersen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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