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LRRTM1 underlies synaptic convergence in visual thalamus

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dc.contributor.authorMonavarfeshani, Aboozaren
dc.contributor.authorStanton, Gailen
dc.contributor.authorVan Name, Jonathanen
dc.contributor.authorSu, Kaiwenen
dc.contributor.authorMills, William A. IIIen
dc.contributor.authorSwilling, Kenyaen
dc.contributor.authorKerr, Aliciaen
dc.contributor.authorHuebschman, Natalie A.en
dc.contributor.authorSu, Jianminen
dc.contributor.authorFox, Michael A.en
dc.contributor.departmentBiological Sciencesen
dc.contributor.departmentFralin Biomedical Research Instituteen
dc.date.accessioned2018-08-28T13:30:21Zen
dc.date.available2018-08-28T13:30:21Zen
dc.date.issued2018-02-09en
dc.description.abstractIt has long been thought that the mammalian visual system is organized into parallel pathways, with incoming visual signals being parsed in the retina based on feature (e.g. color, contrast and motion) and then transmitted to the brain in unmixed, feature-specific channels. To faithfully convey feature-specific information from retina to cortex, thalamic relay cells must receive inputs from only a small number of functionally similar retinal ganglion cells. However, recent studies challenged this by revealing substantial levels of retinal convergence onto relay cells. Here, we sought to identify mechanisms responsible for the assembly of such convergence. Using an unbiased transcriptomics approach and targeted mutant mice, we discovered a critical role for the synaptic adhesion molecule Leucine Rich Repeat Transmembrane Neuronal 1 (LRRTM1) in the emergence of retinothalamic convergence. Importantly, LRRTM1 mutant mice display impairment in visual behaviors, suggesting a functional role of retinothalamic convergence in vision.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.7554/eLife.33498.001en
dc.identifier.orcidFox, Michael A. [0000-0002-1649-7782]en
dc.identifier.orcidMonavarfeshani, Aboozar [0000-0001-8906-5115]en
dc.identifier.urihttp://hdl.handle.net/10919/84927en
dc.identifier.volume7en
dc.language.isoen_USen
dc.publishereLifeen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectRetinogeniculateen
dc.subjectThalamusen
dc.subjectSynaptogenesisen
dc.subjectRetinal ganglion cellen
dc.titleLRRTM1 underlies synaptic convergence in visual thalamusen
dc.title.serialeLifeen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Fralin Biomedical Research Institute at VTC
Destination Area: Adaptive Brain and Behavior (ABB)
Scholarly Works, Biological Sciences