Modeling within-host and aerosol dynamics of SARS-CoV-2: The relationship with infectiousness

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dc.contributor.authorHeitzman-Breen, Noraen
dc.contributor.authorCiupe, Stanca M.en
dc.date.accessioned2022-10-21T12:36:59Zen
dc.date.available2022-10-21T12:36:59Zen
dc.date.issued2022-08en
dc.description.abstractThe relationship between transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the amount of virus present in the proximity of a susceptible host is not understood. Here, we developed a within-host and aerosol mathematical model and used it to determine the relationship between viral kinetics in the upper respiratory track, viral kinetics in the aerosols, and new transmissions in golden hamsters challenged with SARS-CoV-2. We determined that infectious virus shedding early in infection correlates with transmission events, shedding of infectious virus diminishes late in the infection, and high viral RNA levels late in the infection are a poor indicator of transmission. We further showed that viral infectiousness increases in a density dependent manner with viral RNA and that their relative ratio is time-dependent. Such information is useful for designing interventions.en
dc.description.notesSMC and NH-B acknowledge salary support from National Science Foundation grants No. 1813011 and 2051820 and by Virginia Tech Center for Emerging, Zoonotic, and Arthropod -borne Pathogens (CeZAP) seed grant. The funders had no role in study design, data collection and<EM><STRONG> </STRONG></EM>analysis, decision to publish, or preparation of the manuscript.en
dc.description.sponsorshipNational Science Foundation [1813011, 2051820]; Virginia Tech Center for Emerging, Zoonotic; Arthropod -borne Pathogens (CeZAP) seeden
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pcbi.1009997en
dc.identifier.eissn1553-7358en
dc.identifier.issn1553-734Xen
dc.identifier.issue8en
dc.identifier.othere1009997en
dc.identifier.pmid35913988en
dc.identifier.urihttp://hdl.handle.net/10919/112250en
dc.identifier.volume18en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleModeling within-host and aerosol dynamics of SARS-CoV-2: The relationship with infectiousnessen
dc.title.serialPLOS Computational Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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