The Changing Pattern of Nontuberculous Mycobacterial Disease

Falkinham, Joseph O. III

The Changing Pattern of Nontuberculous Mycobacterial Disease

dc.contributor.author	Falkinham, Joseph O. III	en
dc.contributor.department	Biological Sciences	en
dc.date.accessioned	2017-09-18T10:08:26Z	en
dc.date.available	2017-09-18T10:08:26Z	en
dc.date.issued	2003-01-01	en
dc.date.updated	2017-09-18T10:08:26Z	en
dc.description.abstract	Nontuberculous mycobacteria are human opportunistic pathogens whose source of infection is the environment. These include both slow-growing (eg, Mycobacterium kansasii and Mycobacterium avium) and rapid-growing (eg, Mycobacterium abscessus and Mycobacterium fortuitum) species. Transmission is through ingestion or inhalation of water, particulate matter or aerosols, or through trauma. The historic presentation of pulmonary disease in older individuals with predisposing lung conditions and in children has been changing. Pulmonary disease in elderly individuals who lack the classic predisposing lung conditions is increasing. Pulmonary disease and hypersensitivity pneumonitis have been linked with occupational or home exposures to nontuberculous mycobacteria. There has been a shift from Mycobacterium scrofulaceum to M avium in children with cervical lymphadenitis. Further, individuals who are immunosuppressed due to therapy or HIV-infection are at a greatly increased risk for nontuberculous mycobacterial infection. The changing pattern of nontuberculous mycobacterial disease is due in part to the ability of these pathogens to survive and proliferate in habitats that they share with humans, such as drinking water. The advent of an aging population and an increase in the proportion of immunosuppressed individuals suggest that the prevalence of nontuberculous mycobacterial disease will increase.	en
dc.description.version	Published version	en
dc.format.mimetype	application/pdf	en
dc.identifier.citation	Joseph O Falkinham, “The Changing Pattern of Nontuberculous Mycobacterial Disease,” Canadian Journal of Infectious Diseases, vol. 14, no. 5, pp. 281-286, 2003. doi:10.1155/2003/323058	en
dc.identifier.doi	https://doi.org/10.1155/2003/323058	en
dc.identifier.uri	http://hdl.handle.net/10919/79095	en
dc.language.iso	en	en
dc.publisher	Hindawi	en
dc.rights	Creative Commons Attribution 4.0 International	en
dc.rights.holder	Copyright © 2003 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.	en
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	en
dc.title	The Changing Pattern of Nontuberculous Mycobacterial Disease	en
dc.title.serial	Canadian Journal of Infectious Diseases	en
dc.type	Article - Refereed	en
dc.type.dcmitype	Text	en