Estrogen receptor α drives pro-resilient transcription in mouse models of depression

Simple item page
dc.contributor.authorLorsch, Zachary S.en
dc.contributor.authorLoh, Yong-Hwee Eddieen
dc.contributor.authorPurushothaman, Immanuelen
dc.contributor.authorWalker, Deena M.en
dc.contributor.authorParise, Eric M.en
dc.contributor.authorSalery, Marineen
dc.contributor.authorCahill, Michael E.en
dc.contributor.authorHodes, Georgia E.en
dc.contributor.authorPfau, Madeline L.en
dc.contributor.authorKronman, Hopeen
dc.contributor.authorHamilton, Peter J.en
dc.contributor.authorIssler, Ornaen
dc.contributor.authorLabonte, Benoiten
dc.contributor.authorSymonds, Ann E.en
dc.contributor.authorZucker, Matthewen
dc.contributor.authorZhang, Tie Yuanen
dc.contributor.authorMeaney, Michael J.en
dc.contributor.authorRusso, Scott J.en
dc.contributor.authorShen, Lien
dc.contributor.authorBagot, Rosemary C.en
dc.contributor.authorNestler, Eric J.en
dc.contributor.departmentSchool of Neuroscienceen
dc.date.accessioned2018-09-11T14:46:22Zen
dc.date.available2018-09-11T14:46:22Zen
dc.date.issued2018-03-16en
dc.description.abstractMost people exposed to stress do not develop depression. Animal models have shown that stress resilience is an active state that requires broad transcriptional adaptations, but how this homeostatic process is regulated remains poorly understood. In this study, we analyze upstream regulators of genes differentially expressed after chronic social defeat stress. We identify estrogen receptor α (ERα) as the top regulator of pro-resilient transcriptional changes in the nucleus accumbens (NAc), a key brain reward region implicated in depression. In accordance with these findings, nuclear ERα protein levels are altered by stress in male and female mice. Further, overexpression of ERα in the NAc promotes stress resilience in both sexes. Subsequent RNA-sequencing reveals that ERα overexpression in NAc reproduces the transcriptional signature of resilience in male, but not female, mice. These results indicate that NAc ERα is an important regulator of pro-resilient transcriptional changes, but with sex-specific downstream targets.en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41467-018-03567-4en
dc.identifier.urihttp://hdl.handle.net/10919/84997en
dc.identifier.volume9en
dc.language.isoen_USen
dc.publisherNature Publishing Groupen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleEstrogen receptor α drives pro-resilient transcription in mouse models of depressionen
dc.title.serialNature Communicationsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
s41467-018-03567-4.pdf
Size:
1.7 MB
Format:
Adobe Portable Document Format
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
1.5 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Scholarly Works, School of Neuroscience
Destination Area: Adaptive Brain and Behavior (ABB)