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Image Reconstruction For Bioluminescence Tomography From Partial Measurement

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dc.contributor.authorJiang, Mingen
dc.contributor.authorZhou, Tieen
dc.contributor.authorCheng, Jiantaoen
dc.contributor.authorCong, Wenxiangen
dc.contributor.authorWang, Geen
dc.contributor.departmentSchool of Biomedical Engineering and Sciencesen
dc.date.accessed2014-02-24en
dc.date.accessioned2014-04-04T15:12:19Zen
dc.date.available2014-04-04T15:12:19Zen
dc.date.issued2007-09-01en
dc.description.abstractThe bioluminescence tomography is a novel molecular imaging technology for small animal studies. Known reconstruction methods require the completely measured data on the external surface, although only partially measured data is available in practice. In this work, we formulate a mathematical model for BLT from partial data and generalize our previous results on the solution uniqueness to the partial data case. Then we extend two of our reconstruction methods for BLT to this case. The first method is a variant of the well-known EM algorithm. The second one is based on the Landweber scheme. Both methods allow the incorporation of knowledge-based constraints. Two practical constraints, the source non-negativity and support constraints, are introduced to regularize the BLT problem and produce stability. The initial choice of both methods and its influence on the regularization and stability are also discussed. The proposed algorithms are evaluated and validated with intensive numerical simulation and a physical phantom experiment. Quantitative results including the location and source power accuracy are reported. Various algorithmic issues are investigated, especially how to avoid the inverse crime in numerical simulations. (c) 2007 Optical Society of America.en
dc.description.sponsorshipNKBRSF (2003CB716101)en
dc.description.sponsorshipNSFC (60325101, 60532080, 60628102)en
dc.description.sponsorshipChinese Ministry of Education (306017)en
dc.description.sponsorshipEngineering Research Institute of Peking Universityen
dc.description.sponsorshipMicrosoft Research of Asiaen
dc.description.sponsorshipNIH/NIBIB (EB001685)en
dc.description.sponsorshipspecial grant for bioluminescent imaging from Department of Radiology, College of Medicine, University of Iowaen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationMing Jiang, Tie Zhou, Jiantao Cheng, Wenxiang Cong, and Ge Wang, "Image reconstruction for bioluminescence tomography from partial measurement," Opt. Express 15, 11095-11116 (2007). doi: 10.1364/oe.15.011095en
dc.identifier.doihttps://doi.org/10.1364/oe.15.011095en
dc.identifier.issn1094-4087en
dc.identifier.urihttp://hdl.handle.net/10919/46915en
dc.identifier.urlhttp://www.opticsinfobase.org/oe/abstract.cfm?URI=oe-15-18-11095en
dc.language.isoenen
dc.publisherOptical Society of Americaen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectIll-posed problemsen
dc.subjectIn-vivoen
dc.subjectFluorescence tomographyen
dc.subjectOpticalen
dc.subjectTomographyen
dc.subjectLighten
dc.subjectRegularizationen
dc.subjectIterationen
dc.titleImage Reconstruction For Bioluminescence Tomography From Partial Measurementen
dc.title.serialOptics Expressen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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