Guidelines for experimental models of myocardial ischemia and infarction

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dc.contributor.authorLindsey, Merry L.en
dc.contributor.authorBolli, Robertoen
dc.contributor.authorCanty, John M., Jr.en
dc.contributor.authorDu, Xiao-Junen
dc.contributor.authorFrangogiannis, Nikolaos G.en
dc.contributor.authorFrantz, Stefanen
dc.contributor.authorGourdie, Robert G.en
dc.contributor.authorHolmes, Jeffrey W.en
dc.contributor.authorJones, Steven P.en
dc.contributor.authorKloner, Robert A.en
dc.contributor.authorLefer, David J.en
dc.contributor.authorLiao, Ronglihen
dc.contributor.authorMurphy, Elizabethen
dc.contributor.authorPing, Peipeien
dc.contributor.authorPrzyklenk, Karinen
dc.contributor.authorRecchia, Fahio A.en
dc.contributor.authorLongacre, Lisa Schwartzen
dc.contributor.authorRipplinger, Crystal M.en
dc.contributor.authorVan Eyk, Jennifer E.en
dc.contributor.authorHeusch, Gerden
dc.date.accessioned2019-09-03T18:48:06Zen
dc.date.available2019-09-03T18:48:06Zen
dc.date.issued2018-04en
dc.description.abstractMyocardial infarction is a prevalent major cardiovascular event that arises from myocardial ischemia with or without reperfusion, and basic and translational research is needed to better understand its underlying mechanisms and consequences for cardiac structure and function. Ischemia underlies a broad range of clinical scenarios ranging from angina to hibernation to permanent occlusion, and while reperfusion is mandatory for salvage from ischemic injury, reperfusion also inflicts injury on its own. In this consensus statement, we present recommendations for animal models of myocardial ischemia and infarction. With increasing awareness of the need for rigor and reproducibility in designing and performing scientific research to ensure validation of results, the goal of this review is to provide best practice information regarding myocardial ischemia-reperfusion and infarction models. Listen to this article's corresponding podcast at ajpheart.podbean.com/e/guidelines-for-experimental-models-of-myocardial-ischemia-and-infarction/.en
dc.description.notesWe acknowledge support from the following: National Institutes of Health Grants HL-002066, HL-051971, HL-056728, HL-061610, HL-075360, HL-078825, HL-088533, HL-092141, HL-093579, HL-107153, HL-111600, HL-112730, HL-112831, HL-113452, HL-113530, HL-116449, HL-128135, HL-129120, HL-129823, HL-130266, HL-131647, HL-132075, HL-135772, GM-103492, HL-131647, HL-76246, HL-85440, GM-104357, GM-114833, GM-115428, and UL1-TR-001412; American Heart Association Grants 16GRNT30960054 and 16CSA28880004; Grand Challenge Award; Department of Defense Grants 16W81XWH-16-1-0592, PR151051, PR151134, and PR151029; Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development Awards 1IO1BX002659 and I01BX000505; Australian National Health and Medical Research Council Research Fellowship APP1043026; Bundesministerium fur Bildung and Forschung Grant BMBF01 EO1004; and German Research Foundation Grants DFG He 1320/18-3 and SFB 1116 B8. R. A. Kloner reports grant support from Stealth Biotherapeutics, Servier, Inc., and Faraday to test experimental compounds in experimental myocardial infarction models.en
dc.description.sponsorshipNational Institutes of Health [HL-002066, HL-051971, HL-056728, HL-061610, HL-075360, HL-078825, HL-088533, HL-092141, HL-093579, HL-107153, HL-111600, HL-112730, HL-112831, HL-113452, HL-113530, HL-116449, HL-128135, HL-129120]; American Heart Association [16GRNT30960054, 16CSA28880004]; Grand Challenge Award; Department of Defense [16W81XWH-16-1-0592, PR151051, PR151134, PR151029]; Biomedical Laboratory Research and Development Service of the Veterans Affairs Office of Research and Development [1IO1BX002659, I01BX000505]; Australian National Health and Medical Research Council [APP1043026]; Bundesministerium fur Bildung and Forschung [BMBF01 EO1004]; German Research Foundation [DFG He 1320/18-3, SFB 1116 B8]; Stealth Biotherapeutics; Servier, Inc.; Faraday; The National Institutes of Health [HL-129823, HL-130266, HL-131647, HL-132075, HL-135772, GM-103492, HL-76246, HL-85440, GM-104357, GM-114833, GM-115428, UL1-TR-001412]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1152/ajpheart.00335.2017en
dc.identifier.eissn1522-1539en
dc.identifier.issn0363-6135en
dc.identifier.issue4en
dc.identifier.pmid29351451en
dc.identifier.urihttp://hdl.handle.net/10919/93338en
dc.identifier.volume314en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectanimal modelsen
dc.subjectcardiac remodelingen
dc.subjectheart failureen
dc.subjectmyocardial infarctionen
dc.subjectreperfusonen
dc.subjectrigor and reproducibilityen
dc.titleGuidelines for experimental models of myocardial ischemia and infarctionen
dc.title.serialAmerican Journal of Physiology-Heart and Circulatory Physiologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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