Remote Actuation of Magnetic Nanoparticles For Cancer Cell Selective Treatment Through Cytoskeletal Disruption

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dc.contributor.authorMaster, Alyssa M.en
dc.contributor.authorWilliams, Philise N.en
dc.contributor.authorPothayee, Nikornen
dc.contributor.authorPothayee, Niponen
dc.contributor.authorZhang, Ruien
dc.contributor.authorVishwasrao, Hemant M.en
dc.contributor.authorGolovin, Yuri I.en
dc.contributor.authorRiffle, Judy S.en
dc.contributor.authorSokolsky, Marinaen
dc.contributor.authorKabanov, Alexander V.en
dc.date.accessioned2019-01-22T18:54:43Zen
dc.date.available2019-01-22T18:54:43Zen
dc.date.issued2016-09-20en
dc.description.abstractMotion of micron and sub-micron size magnetic particles in alternating magnetic fields can activate mechanosensitive cellular functions or physically destruct cancer cells. However, such effects are usually observed with relatively large magnetic particles (> 250 nm) that would be difficult if at all possible to deliver to remote sites in the body to treat disease. Here we show a completely new mechanism of selective toxicity of superparamagnetic nanoparticles (SMNP) of 7 to 8 nm in diameter to cancer cells. These particles are coated by block copolymers, which facilitates their entry into the cells and clustering in the lysosomes, where they are then magneto-mechanically actuated by remotely applied alternating current (AC) magnetic fields of very low frequency (50 Hz). Such fields and treatments are safe for surrounding tissues but produce cytoskeletal disruption and subsequent death of cancer cells while leaving healthy cells intact.en
dc.description.notesThe Carolina Partnership, a strategic partnership between the UNC Eshelman School of Pharmacy, The University Cancer Research Fund through the Lineberger 32 Comprehensive Cancer Center and the grant from the UNC Eshelman Institute for Innovation, in part supported this work.en
dc.description.sponsorshipUNC Eshelman Institute for Innovationen
dc.format.extent13en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/srep33560en
dc.identifier.issn2045-2322en
dc.identifier.other33560en
dc.identifier.pmid27644858en
dc.identifier.urihttp://hdl.handle.net/10919/86835en
dc.identifier.volume6en
dc.language.isoen_USen
dc.publisherSpringer Natureen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectlysosomal membrane permeabilizationen
dc.subjectoxide nanoparticlesen
dc.subjecthyperthermiaen
dc.subjectApoptosisen
dc.subjectfieldsen
dc.subjecttherapyen
dc.subjectdeathen
dc.subjecttimeen
dc.titleRemote Actuation of Magnetic Nanoparticles For Cancer Cell Selective Treatment Through Cytoskeletal Disruptionen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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