Body Weight Selection Affects Quantitative Genetic Correlated Responses in Gut Microbiota

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dc.contributor.authorMeng, Heen
dc.contributor.authorZhang, Yanen
dc.contributor.authorZhao, Leleen
dc.contributor.authorZhao, Wenjingen
dc.contributor.authorHe, Chuanen
dc.contributor.authorHonaker, Christa F.en
dc.contributor.authorZhai, Zhengxiaoen
dc.contributor.authorSun, Zikuien
dc.contributor.authorSiegel, Paul B.en
dc.contributor.departmentAnimal and Poultry Sciencesen
dc.contributor.departmentFralin Life Sciences Instituteen
dc.date.accessioned2018-10-10T19:22:27Zen
dc.date.available2018-10-10T19:22:27Zen
dc.date.issued2014-03-07en
dc.description.abstractThe abundance of gut microbiota can be viewed as a quantitative trait, which is affected by the genetics and environment of the host. To quantify the effects of host genetics, we calculated the heritability of abundance of specific microorganisms and genetic correlations among them in the gut microbiota of two lines of chickens maintained under the same husbandry and dietary regimes. The lines, which originated from a common founder population, had undergone >50 generations of selection for high (HW) or low (LW) 56-day body weight and now differ by more than 10-fold in body weight at selection age. We identified families of Paenibacillaceae, Streptococcaceae, Helicobacteraceae, and Burkholderiaceae that had moderate heritabilities. Although there were no obvious phenotypic correlations among gut microbiota, significant genetic correlations were observed. Moreover, the effects were modified by genetic selection for body weight, which altered the quantitative genetic background of the host. Heritabilities for Bacillaceae, Flavobacteriaceae, Helicobacteraceae, Comamonadaceae, Enterococcaceae, and Streptococcaceae were moderate in LW line and little to zero in the HW line. These results suggest that loci associated with these microbiota families, while exhibiting genetic variation in LW, have been fixed in HW line. Also, long term selection for body weight has altered the genetic correlations among gut microbiota. No microbiota families had significant heritabilities in both the LW and HW lines suggesting that the presence and/or absence of a particular microbiota family either has a strong growth promoting or inhibiting effect, but not both. These results demonstrate that the quantitative genetics of the host have considerable influence on the gut microbiota.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0089862en
dc.identifier.eissn1932-6203en
dc.identifier.issue3en
dc.identifier.othere89862en
dc.identifier.pmid24608294en
dc.identifier.urihttp://hdl.handle.net/10919/85340en
dc.identifier.volume9en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleBody Weight Selection Affects Quantitative Genetic Correlated Responses in Gut Microbiotaen
dc.title.serialPLOS ONEen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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