Molecular mechanisms of experience-dependent plasticity in visual cortex

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dc.contributor.authorVan Wart, Audraen
dc.contributor.authorTropea, Danielaen
dc.contributor.authorSur, Mrigankaen
dc.date.accessioned2018-03-23T13:09:02Zen
dc.date.available2018-03-23T13:09:02Zen
dc.date.issued2008en
dc.description.abstractA remarkable amount of our current knowledge of mechanisms underlying experience-dependent plasticity during cortical development comes from study of the mammalian visual cortex. Recent advances in high-resolution cellular imaging, combined with genetic manipulations in mice, novel fluorescent recombinant probes, and large-scale screens of gene expression, have revealed multiple molecular mechanisms that underlie structural and functional plasticity in visual cortex. We situate these mechanisms in the context of a new conceptual framework of feed-forward and feedback regulation for understanding how neurons of the visual cortex reorganize their connections in response to changes in sensory inputs. Such conceptual advances have important implications for understanding not only normal development but also pathological conditions that afflict the central nervous system.en
dc.description.notespp. 341-355en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1098/rstb.2008.0269en
dc.identifier.issue364en
dc.identifier.urihttp://hdl.handle.net/10919/82550en
dc.identifier.urlhttp://rstb.royalsocietypublishing.org/content/364/1515/341en
dc.identifier.volume2009en
dc.language.isoen_USen
dc.publisherRoyal Societyen
dc.rightsCreative Commons Attribution 3.0 United Statesen
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/en
dc.subjectOcular dominance plasticityen
dc.subjectCritical perioden
dc.subjectSynapsesen
dc.subjectFeed-forward regulationen
dc.subjectFeedback regulationen
dc.subjectHomeostasisen
dc.titleMolecular mechanisms of experience-dependent plasticity in visual cortexen
dc.title.serialPhilosophical Transactions of the Royal Society Ben
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Fralin Biomedical Research Institute at VTC
Destination Area: Adaptive Brain and Behavior (ABB)