Hippocampal Deletion of BDNF Gene Attenuates Gamma Oscillations in Area CA1 by Up-Regulating 5-HT3 Receptor

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dc.contributor.authorHuang, Yingen
dc.contributor.authorMorozov, Alexeien
dc.date.accessioned2019-06-03T21:03:11Zen
dc.date.available2019-06-03T21:03:11Zen
dc.date.issued2011-01-26en
dc.description.abstractBackground: Pyramidal neurons in the hippocampal area CA3 express high levels of BDNF, but how this BDNF contributes to oscillatory properties of hippocampus is unknown. Methodology/Principal Findings: Here we examined carbachol-induced gamma oscillations in hippocampal slices lacking BDNF gene in the area CA3. The power of oscillations was reduced in the hippocampal area CA1, which coincided with increases in the expression and activity of 5-HT3 receptor. Pharmacological block of this receptor partially restored power of gamma oscillations in slices from KO mice, but had no effect in slices from WT mice. Conclusion/Significance: These data suggest that BDNF facilitates gamma oscillations in the hippocampus by attenuating signaling through 5-HT3 receptor. Thus, BDNF modulates hippocampal oscillations through serotonergic system.en
dc.description.sponsorshipNational Institutes of Health National Institute of Mental Health Intramural Research Programen
dc.format.extent7 pagesen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationHuang Y, Morozov A (2011) Hippocampal Deletion of BDNF Gene Attenuates Gamma Oscillations in Area CA1 by Up-Regulating 5-HT3 Receptor. PLoS ONE 6(1): e16480. doi:10.1371/journal.pone.0016480en
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0016480en
dc.identifier.issue1en
dc.identifier.urihttp://hdl.handle.net/10919/89728en
dc.identifier.volume6en
dc.language.isoenen
dc.publisherPLOSen
dc.rightsCreative Commons CC0 1.0 Universal Public Domain Dedicationen
dc.rights.urihttp://creativecommons.org/publicdomain/zero/1.0/en
dc.titleHippocampal Deletion of BDNF Gene Attenuates Gamma Oscillations in Area CA1 by Up-Regulating 5-HT3 Receptoren
dc.title.serialPLOS Oneen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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