Chemical modification of shaped hydrogels in non-aqueous medium
| dc.contributor.assignee | Center for Innovative Technology | en |
| dc.contributor.assignee | Virginia Polytechnic Institute and State University | en |
| dc.contributor.assignee | Virginia Tech Intellectual Properties, Inc. | en |
| dc.contributor.inventor | Glasser, Wolfgang G. | en |
| dc.contributor.inventor | Frazier, Charles E. | en |
| dc.contributor.inventor | Samaranayake, Gamini S. | en |
| dc.date.accessed | 2016-08-19 | en |
| dc.date.accessioned | 2016-08-24T17:53:47Z | en |
| dc.date.available | 2016-08-24T17:53:47Z | en |
| dc.date.filed | 1994-08-29 | en |
| dc.date.issued | 1996-06-25 | en |
| dc.description.abstract | A method is described for the chemical modification of pre-shaped hydrogels in non-aqueous medium. The conditions permit the reaction of highly expanded, porous hydrogel particles, such as spherical beads, using pseudo homogeneous reaction conditions in the absence of water. The method involves a three step procedure in which the porous gels are solvent exchanged int a water-free solvent (step 1) with minimal change in gel dimension and porosity; followed by reaction under non-aqueous condition (step 2); and followed by solvent exchange into water (step 3). Many different types of reactions requiring non-aqueous conditions may be carried out using these conditions. The method has particularly been demonstrated for crosslinking fluorinating beads, and for esterifying beads in a reaction involving multifunctional free carboxylic acids in the presence of dicyclohexylcarbodiimide (DCC). | en |
| dc.format.mimetype | application/pdf | en |
| dc.identifier.applicationnumber | 8296171 | en |
| dc.identifier.patentnumber | 5530111 | en |
| dc.identifier.uri | http://hdl.handle.net/10919/72320 | en |
| dc.identifier.url | http://pimg-fpiw.uspto.gov/fdd/11/301/055/0.pdf | en |
| dc.language.iso | en_US | en |
| dc.publisher | United States Patent and Trademark Office | en |
| dc.subject.cpc | C08B3/00 | en |
| dc.subject.cpc | C08B3/14 | en |
| dc.subject.uspc | 536/56 | en |
| dc.subject.uspcother | 536/58 | en |
| dc.subject.uspcother | 536/84 | en |
| dc.subject.uspcother | 536/124 | en |
| dc.title | Chemical modification of shaped hydrogels in non-aqueous medium | en |
| dc.type | Patent | en |
| dc.type.dcmitype | Text | en |
| dc.type.patenttype | utility | en |
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