Modeling-enabled Systems Nutritional Immunology

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dc.contributor.authorVerma, Meghnaen
dc.contributor.authorHontecillas, Raquelen
dc.contributor.authorAbedi, Vidaen
dc.contributor.authorLeber, Andrewen
dc.contributor.authorTubau-Juni, Nuriaen
dc.contributor.authorPhilipson, Casandraen
dc.contributor.authorCarbo, Adriaen
dc.contributor.authorBassaganya-Riera, Josepen
dc.date.accessioned2019-11-01T19:24:40Zen
dc.date.available2019-11-01T19:24:40Zen
dc.date.issued2016-02-16en
dc.description.abstractThis review highlights the fundamental role of nutrition in the maintenance of health, the immune response, and disease prevention. Emerging global mechanistic insights in the field of nutritional immunology cannot be gained through reductionist methods alone or by analyzing a single nutrient at a time. We propose to investigate nutritional immunology as a massively interacting system of interconnected multistage and multiscale networks that encompass hidden mechanisms by which nutrition, microbiome, metabolism, genetic predisposition, and the immune system interact to delineate health and disease. The review sets an unconventional path to apply complex science methodologies to nutritional immunology research, discovery, and development through "use cases" centered around the impact of nutrition on the gut microbiome and immune responses. Our systems nutritional immunology analyses, which include modeling and informatics methodologies in combination with pre-clinical and clinical studies, have the potential to discover emerging systems-wide properties at the interface of the immune system, nutrition, microbiome, and metabolism.en
dc.description.notesFunding provided by Nutritional Immunology and Molecular Medicine Laboratory (www.nimml.org).en
dc.description.sponsorshipNutritional Immunology and Molecular Medicine Laboratoryen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fnut.2016.00005en
dc.identifier.issn2296-861Xen
dc.identifier.otherUNSP 5en
dc.identifier.pmid26909350en
dc.identifier.urihttp://hdl.handle.net/10919/95231en
dc.identifier.volume3en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectNutritional immunologyen
dc.subjectNutritionen
dc.subjectsystems biologyen
dc.subjectinformaticsen
dc.subjectcomputational modelingen
dc.subjectbig dataen
dc.subjectcomplex systemsen
dc.titleModeling-enabled Systems Nutritional Immunologyen
dc.title.serialFrontiers in Nutritionen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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