Metastatic Multiple Myeloma to the Skin

Simple item page
dc.contributor.authorHolliday, Alex C.en
dc.contributor.authorKhan, Mohammed I.en
dc.contributor.authorMazloom, Sean E.en
dc.contributor.authorChavan, Rahul N.en
dc.contributor.authorGrider, Douglas J.en
dc.date.accessioned2019-12-23T13:30:53Zen
dc.date.available2019-12-23T13:30:53Zen
dc.date.issued2019-11-12en
dc.date.updated2019-12-23T13:25:45Zen
dc.description.abstractCutaneous involvement of multiple myeloma (MM) is uncommon, typically occurs in late stage disease, and is a poor prognostic indicator with an approximate eight month median survival. We present a 51-year-old man with relapsed lambda light chain MM who developed abrupt asymptomatic skin metastases. Biopsy revealed a dermis replete of atypical plasma cells, positive for CD138 and CD45. In situ hybridization confirmed lambda light chain restriction. Despite rescue antimyeloma therapy with the anti-CD38 drug daratumumab, he rapidly declined clinically and succumbed to the disease four weeks after presentation. A standard treatment approach for cutaneous MM does not currently exist; however, various techniques to detect cytogenetic abnormalities are emerging and will provide additional prognostic value and direct individualized therapy.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.citationAlex C. Holliday, Mohammed I. Khan, Sean E. Mazloom, Rahul N. Chavan, and Douglas J. Grider, “Metastatic Multiple Myeloma to the Skin,” Case Reports in Dermatological Medicine, vol. 2019, Article ID 7930123, 3 pages, 2019. doi:10.1155/2019/7930123en
dc.identifier.doihttps://doi.org/10.1155/2019/7930123en
dc.identifier.urihttp://hdl.handle.net/10919/96204en
dc.language.isoenen
dc.publisherHindawien
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.holderCopyright © 2019 Alex C. Holliday et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.titleMetastatic Multiple Myeloma to the Skinen
dc.title.serialCase Reports in Dermatological Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 2 of 2
Thumbnail Image
Name:
CRIDM.2019.7930123.pdf
Size:
1.11 MB
Format:
Adobe Portable Document Format
Download
Name:
CRIDM.2019.7930123.xml
Size:
6.6 KB
Format:
Extensible Markup Language
Download
License bundle
Now showing 1 - 1 of 1
Name:
license.txt
Size:
0 B
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

Journal Articles, Hindawi Press
Scholarly Works, Virginia Tech Carilion School of Medicine (VTCSOM)