Glial Activation in the Thalamus Contributes to Vestibulomotor Deficits Following Blast-Induced Neurotrauma

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dc.contributor.authorDickerson, Michelle R.en
dc.contributor.authorBailey, Zachary S.en
dc.contributor.authorMurphy, Susan F.en
dc.contributor.authorUrban, Michael J.en
dc.contributor.authorVandeVord, Pamela J.en
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessioned2020-11-13T19:30:48Zen
dc.date.available2020-11-13T19:30:48Zen
dc.date.issued2020-07-15en
dc.description.abstractVestibular impairment has become a frequent consequence following blast-related traumatic brain injury (bTBI) in military personnel and Veterans. Behavioral outcomes such as depression, fear and anxiety are also common comorbidities of bTBI. To accelerate pre-clinical research and therapy developments, there is a need to study the link between behavioral patterns and neuropathology. The transmission of neurosensory information often involves a pathway from the cerebral cortex to the thalamus, and the thalamus serves crucial integrative functions within vestibular processing. Pathways from the thalamus also connect with the amygdala, suggesting thalamic and amygdalar contributions to anxiolytic behavior. Here we used behavioral assays and immunohistochemistry to determine the sub-acute and early chronic effects of repeated blast exposure on the thalamic and amygdala nuclei. Behavioral results indicated vestibulomotor deficits at 1 and 3 weeks following repeated blast events. Anxiety-like behavior assessments depicted trending increases in the blast group. Astrogliosis and microglia activation were observed upon post-mortem pathological examination in the thalamic region, along with a limited glia response in the amygdala at 4 weeks. These findings are consistent with a diffuse glia response associated with bTBI and support the premise that dysfunction within the thalamic nuclei following repeated blast exposures contribute to vestibulomotor impairment.en
dc.description.notesThis work was supported by Merit Review Award number RX001104-01 from the United States Department of Veterans Affairs Rehabilitation Research and Development Service Program (PI: PV).en
dc.description.sponsorshipMerit Review Award from United States Department of Veterans Affairs Rehabilitation Research and Development Service Program [RX001104-01]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fneur.2020.00618en
dc.identifier.issn1664-2295en
dc.identifier.other618en
dc.identifier.pmid32760340en
dc.identifier.urihttp://hdl.handle.net/10919/100856en
dc.identifier.volume11en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectthalamusen
dc.subjectamygdalaen
dc.subjectblasten
dc.subjectvestibulomotoren
dc.subjectmicrogliaen
dc.subjectastrocytesen
dc.subjecttraumatic brain injuryen
dc.titleGlial Activation in the Thalamus Contributes to Vestibulomotor Deficits Following Blast-Induced Neurotraumaen
dc.title.serialFrontiers In Neurologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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Scholarly Works, Biomedical Engineering and Mechanics
Destination Area: Adaptive Brain and Behavior (ABB)