Clinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulation

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dc.contributor.authorCollins, Caitlyn J.en
dc.contributor.authorAtkins, Penny R.en
dc.contributor.authorOhs, Nicholasen
dc.contributor.authorBlauth, Michaelen
dc.contributor.authorLippuner, Kurten
dc.contributor.authorMueller, Ralphen
dc.date.accessioned2023-04-27T12:45:01Zen
dc.date.available2023-04-27T12:45:01Zen
dc.date.issued2022-10en
dc.description.abstractHigh resolution peripheral quantitative computed tomography (HR-pQCT) provides methods for quantifying volumetric bone mineral density and microarchitecture necessary for early diagnosis of bone disease. When combined with a longitudinal imaging protocol and finite element analysis, HR-pQCT can be used to assess bone formation and resorption (i.e., remodeling) and the relationship between this remodeling and mechanical loading (i.e., mechanoregulation) at the tissue level. Herein, 25 patients with a contralateral distal radius fracture were imaged with HR-pQCT at baseline and 9-12 months follow-up: 16 patients were prescribed vitamin D3 with/without calcium supplement based on a blood biomarker measures of bone metabolism and dual-energy X-ray absorptiometry image-based measures of normative bone quantity which indicated diminishing (n = 9) or poor (n = 7) bone quantity and 9 were not. To evaluate the sensitivity of this imaging protocol to microstructural changes, HR-pQCT images were registered for quantification of bone remodeling and image-based micro-finite element analysis was then used to predict local bone strains and derive rules for mechanoregulation. Remodeling volume fractions were predicted by both average values of trabecular and cortical thickness and bone mineral density (R-2 > 0.8), whereas mechanoregulation was affected by dominance of the arm and group classification (p < 0.05). Overall, longitudinal, extended HR-pQCT analysis enabled the identification of changes in bone quantity and quality too subtle for traditional measures.en
dc.description.notesThe authors acknowledge the Swiss National Science Foundation (320030L_170205), the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska -Curie grant (agreement 841316), and the ETH Postdoctoral Fellowship for financial support. This work was supported by a grant from the Swiss National Supercomputing Centre (CSCS) under project ID s841 and s1070.en
dc.description.sponsorshipSwiss National Science Foundation [320030L_170205]; European Union [841316]; ETH Postdoctoral Fellowship; Swiss National Supercomputing Centre (CSCS) [s841, s1070]en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1038/s41598-022-22678-zen
dc.identifier.issue1en
dc.identifier.other17960en
dc.identifier.pmid36289391en
dc.identifier.urihttp://hdl.handle.net/10919/114812en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherNature Portfolioen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectDistal radiusen
dc.subjectcomputed-tomographyen
dc.subjectpostmenopausal womenen
dc.subjectmineral densityen
dc.subjectfracture risken
dc.subjecthip fractureen
dc.subjectelderly-menen
dc.subjectstrengthen
dc.subjecttibiaen
dc.subjectmicroarchitectureen
dc.titleClinical observation of diminished bone quality and quantity through longitudinal HR-pQCT-derived remodeling and mechanoregulationen
dc.title.serialScientific Reportsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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