Neural differences in self-perception during illness and after weight-recovery in anorexia nervosa

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dc.contributorVirginia Techen
dc.contributor.authorMcAdams, Carrie J.en
dc.contributor.authorJeon-Slaughter, Haekyungen
dc.contributor.authorEvans, Siobahnen
dc.contributor.authorLohrenz, Terryen
dc.contributor.authorMontague, P. Readen
dc.contributor.authorKrawczyk, Daniel C.en
dc.date.accessioned2017-09-07T14:38:18Zen
dc.date.available2017-09-07T14:38:18Zen
dc.date.issued2016-06-27en
dc.description.abstractAnorexia nervosa (AN) is a severe mental illness characterized by problems with self-perception. Whole-brain neural activations in healthy women, women with AN and women in long-term weight recovery following AN were compared using two functional magnetic resonance imaging tasks probing different aspects of self-perception. The Social Identity-V2 task involved consideration about oneself and others using socially descriptive adjectives. Both the ill and weight-recovered women with AN engaged medial prefrontal cortex less than healthy women for self-relevant cognitions, a potential biological trait difference. Weight-recovered women also activated the inferior frontal gyri and dorsal anterior cingulate more for direct self-evaluations than for reflected self-evaluations, unlike both other groups, suggesting that recovery may include compensatory neural changes related to social perspectives. The Faces task compared viewing oneself to a stranger. Participants with AN showed elevated activity in the bilateral fusiform gyri for self-images, unlike the weight-recovered and healthy women, suggesting cognitive distortions about physical appearance are a state rather than trait problem in this disease. Because both ill and recovered women showed neural differences related to social self-perception, but only recovered women differed when considering social perspectives, these neurocognitive targets may be particularly important for treatment.en
dc.identifier.doihttps://doi.org/10.1093/scan/nsw092en
dc.identifier.issue11en
dc.identifier.urihttp://hdl.handle.net/10919/78818en
dc.identifier.volume11en
dc.language.isoen_USen
dc.publisherOxforden
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjecteating disordersen
dc.subjectmedial prefrontal cortexen
dc.subjectself-reflectionen
dc.subjectfMRIen
dc.subjectpsychiatryen
dc.titleNeural differences in self-perception during illness and after weight-recovery in anorexia nervosaen
dc.title.serialSocial Cognitive and Affective Neuroscienceen
dc.typeArticle - Refereeden

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