Diversity in growth patterns among strains of the lethal fungal pathogen Batrachochytrium dendrobatidis across extended thermal optima

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dc.contributor.authorVoyles, Jamieen
dc.contributor.authorJohnson, Leah R.en
dc.contributor.authorRohr, Jason R.en
dc.contributor.authorKelly, Rochelleen
dc.contributor.authorBarron, Carleyen
dc.contributor.authorMiller, Delaneyen
dc.contributor.authorMinster, Joshen
dc.contributor.authorRosenblum, Erica Breeen
dc.contributor.departmentStatisticsen
dc.date.accessioned2019-10-04T17:40:05Zen
dc.date.available2019-10-04T17:40:05Zen
dc.date.issued2017-06en
dc.description.abstractThe thermal sensitivities of organisms regulate a wide range of ecological interactions, including host-parasite dynamics. The effect of temperature on disease ecology can be remarkably complex in disease systems where the hosts are ectothermic and where thermal conditions constrain pathogen reproductive rates. Amphibian chytridiomycosis, caused by the pathogen Batrachochytrium dendrobatidis (Bd), is a lethal fungal disease that is influenced by temperature. However, recent temperature studies have produced contradictory findings, suggesting that our current understanding of thermal effects on Bd may be incomplete. We investigated how temperature affects three different Bd strains to evaluate diversity in thermal responses. We quantified growth across the entire thermal range of Bd, and beyond the known thermal limits (T-max and T-min). Our results show that all Bd strains remained viable and grew following 24 h freeze (-12 degrees C) and heat shock (28 degrees C) treatments. Additionally, we found that two Bd strains had higher logistic growth rates (r) and carrying capacities (K) at the upper and lower extremities of the temperature range, and especially in low temperature conditions (2-3 degrees C). In contrast, a third strain exhibited relatively lower growth rates and carrying capacities at these same thermal extremes. Overall, our results suggest that there is considerable variation among Bd strains in thermal tolerance, and they establish a new thermal sensitivity profile for Bd. More generally, our findings point toward important questions concerning the mechanisms that dictate fungal thermal tolerances and temperature-dependent pathogenesis in other fungal disease systems.en
dc.description.notesWe thank Gabriela Rios-Sotelo, Rachel Perez, Cecelia Ogunro and Zachary Gajewski for their assistance with data collection and editing. This study was supported by the National Science Foundation (IOS-13542421 to EBR and JV) and an Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health (P20GM103451 to JV).en
dc.description.sponsorshipNational Science Foundation [IOS-13542421]; Institutional Development Award (IDeA) from the National Institute of General Medical Sciences of the National Institutes of Health [P20GM103451]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1007/s00442-017-3866-8en
dc.identifier.eissn1432-1939en
dc.identifier.issn0029-8549en
dc.identifier.issue2en
dc.identifier.pmid28424893en
dc.identifier.urihttp://hdl.handle.net/10919/94354en
dc.identifier.volume184en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectBatrachochytrium dendrobatidisen
dc.subjectAmphibian chytridiomycosisen
dc.subjectDisease ecologyen
dc.subjectPsychrophilic fungien
dc.subjectTemperatureen
dc.titleDiversity in growth patterns among strains of the lethal fungal pathogen Batrachochytrium dendrobatidis across extended thermal optimaen
dc.title.serialOecologiaen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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