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Shift Workers Have Higher Blood Pressure Medicine Use, But Only When They Are Short Sleepers: A Longitudinal UK Biobank Study

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dc.contributor.authorRiegel, Barbaraen
dc.contributor.authorDaus, Margueriteen
dc.contributor.authorLozano, Alicia J.en
dc.contributor.authorMalone, Susan K.en
dc.contributor.authorPatterson, Fredaen
dc.contributor.authorHanlon, Alexandra L.en
dc.contributor.departmentStatisticsen
dc.date.accessioned2020-02-10T15:32:53Zen
dc.date.available2020-02-10T15:32:53Zen
dc.date.issued2019-10-15en
dc.description.abstractBackground-Some, but not all, studies report associations between shift work and hypertension, suggesting that particular subgroups may be at risk. We examined moderating effects of sleep duration and circadian preference on the relationship between shift work and new blood pressure (BP) medicine use at follow-up. Methods and Results-Baseline and 5-year follow-up data from the UK Biobank cohort (N=9200) were used to generate logistic regression models for shift workers and nonshift workers. The moderating effects of sleep duration (short <= 6 hours; adequate 7-8 hours; long >= 9 hours) and circadian preference (morning "larks;" intermediate; evening "owls") at baseline were examined with new BP medicine use at follow-up, adjusting for age, sex, race, education, employment, urban/rural, cardiovascular disease family history, depression, alcohol intake, physical activity, diet, smoking, and body mass index. The sample was predominately middle aged (55.3 +/- 7.4), female (57.3%), and white (97.9%). Most reported adequate sleep duration (7-8 hours, 73.7%) and were intermediate type (65.3%); 8.0% were shift workers at baseline. Only 6.5% reported new BP medicine use at follow-up. Short sleep duration was a significant moderator of new BP medicine use in shift workers. Among short sleepers, shift workers had a 2.1-fold increased odds of new BP medicine use compared with nonshift workers (odds ratio=2.08, 95% CI=1.21-3.58, P=0.008). In those reporting adequate (odds ratio=0.82, 95% CI=0.54-1.25, P=0.35) and long sleep (odds ratio=0.64, 95% CI=0.11-3.54, P=0.60), this relationship was protective but nonsignificant. Interaction between circadian preference and shift work on BP medicine use was nonsignificant. Conclusions-Shift workers with short sleep duration may be at risk for hypertension.en
dc.description.notesResearch reported in this publication was supported by the National Institute On Minority Health And Health Disparities of the National Institutes of Health under Award Number R01MD012734 (Patterson), the National Institute of Nursing Research (T32NR007104-20) (Daus), the National Institute of Nursing Research (K99NR017416) (Malone) and the National Heart, Lung, and Blood Institute (T32HL7953) (Malone). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.en
dc.description.sponsorshipNational Institute On Minority Health And Health Disparities of the National Institutes of Health [R01MD012734]; National Institute of Nursing ResearchUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Nursing Research (NINR) [T32NR007104-20, K99NR017416]; National Heart, Lung, and Blood InstituteUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [T32HL7953]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1161/JAHA.119.013269en
dc.identifier.issn2047-9980en
dc.identifier.issue20en
dc.identifier.othere013269en
dc.identifier.pmid31581870en
dc.identifier.urihttp://hdl.handle.net/10919/96784en
dc.identifier.volume8en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivatives 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectcircadian rhythmen
dc.subjecthypertensionen
dc.subjectrisk factorsen
dc.subjectshift work scheduleen
dc.subjectsleepen
dc.titleShift Workers Have Higher Blood Pressure Medicine Use, But Only When They Are Short Sleepers: A Longitudinal UK Biobank Studyen
dc.title.serialJournal of the American Heart Associationen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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