Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study

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dc.contributor.authorBoswood, Adrianen
dc.contributor.authorGordon, Sonya G.en
dc.contributor.authorHaggstrom, Jensen
dc.contributor.authorVanselow, Martinen
dc.contributor.authorWess, Gerharden
dc.contributor.authorStepien, Rebecca L.en
dc.contributor.authorOyama, Mark A.en
dc.contributor.authorKeene, Bruce W.en
dc.contributor.authorBonagura, Johnen
dc.contributor.authorMacDonald, Kristin A.en
dc.contributor.authorPatteson, Marken
dc.contributor.authorSmith, Sarahen
dc.contributor.authorFox, Philip R.en
dc.contributor.authorSanderson, Karenen
dc.contributor.authorWoolley, Richarden
dc.contributor.authorSzatmari, Viktoren
dc.contributor.authorMenaut, Pierreen
dc.contributor.authorChurch, Whitney M.en
dc.contributor.authorO'Sullivan, M. Lynneen
dc.contributor.authorJaudon, Jean-Philippeen
dc.contributor.authorKresken, Jan-Gerden
dc.contributor.authorRush, Johnen
dc.contributor.authorBarrett, Kirstie A.en
dc.contributor.authorRosenthal, Steven L.en
dc.contributor.authorSaunders, Ashley B.en
dc.contributor.authorLjungvall, Ingriden
dc.contributor.authorDeinert, Michaelen
dc.contributor.authorBomassi, Ericen
dc.contributor.authorEstrada, Amara H.en
dc.contributor.authorFernandez Del Palacio, Maria J.en
dc.contributor.authorMoise, N. Sydneyen
dc.contributor.authorAbbott, Jonathan A.en
dc.contributor.authorFujii, Yokoen
dc.contributor.authorSpier, Alanen
dc.contributor.authorLuethy, Michael W.en
dc.contributor.authorSantilli, Roberto A.en
dc.contributor.authorUechi, Masamien
dc.contributor.authorTidholm, Annaen
dc.contributor.authorSchummer, Christophen
dc.contributor.authorWatson, Philipen
dc.date.accessioned2020-05-12T12:08:21Zen
dc.date.available2020-05-12T12:08:21Zen
dc.date.issued2020-02en
dc.description.abstractBackground The Evaluation of pimobendan in dogs with cardiomegaly caused by preclinical myxomatous mitral valve disease (EPIC) study monitored dogs with myxomatous mitral valve disease (MMVD) as they developed congestive heart failure (CHF). Objectives To describe the changes in clinical and radiographic variables occurring as dogs with MMVD and cardiomegaly develop CHF, compared to similar dogs that do not develop CHF. Animals One hundred and thirty-five, and 73 dogs that did or did not develop CHF, respectively. Materials and methods The following variables were evaluated in 2 groups of dogs (dogs that did or did not develop CHF): Heart rate (HR), clinic respiratory rate (RR), home-measured resting respiratory rate (RRR), rectal temperature (RT), body weight (BW), and vertebral heart sum (VHS). Absolute value and rate of change of each variable were calculated for each day a dog was in study. Daily means were calculated and plotted against time. The onset of CHF or last visit before leaving the study were set as reference time points. Results The most extreme values and rate of change occurred in variables immediately before onset of CHF. Vertebral heart sum increased earliest. Heart rate, RR, and RRR also increased. Rectal temperature and BW decreased. Increases in RR and RRR were most extreme and occurred immediately before CHF. Conclusions and Clinical Importance Dogs with MMVD and cardiomegaly experience increases in HR, RR, RRR, and VHS, and decreases in BW and RT as they develop CHF. The variables with highest absolute change and rate of change were RR and RRR. These findings reinforce the value of RR and RRR as indicators of impending or incipient CHF.en
dc.description.notesBoehringer Ingelheim Animal Health GmbHen
dc.description.sponsorshipBoehringer Ingelheim Animal Health GmbHBoehringer Ingelheimen
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1111/jvim.15753en
dc.identifier.eissn1939-1676en
dc.identifier.issn0891-6640en
dc.identifier.pmid32200574en
dc.identifier.urihttp://hdl.handle.net/10919/98225en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectcanineen
dc.subjectcardiovascularen
dc.subjectclinical epidemiologyen
dc.subjectclinical trialsen
dc.subjectheart failureen
dc.subjectphysical examinationen
dc.subjectradiology and diagnostic imagingen
dc.titleTemporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC studyen
dc.title.serialJournal of Veterinary Internal Medicineen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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