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Comparing Effectiveness of Top-Down and Bottom-Up Strategies in Containing Influenza

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dc.contributorVirginia Techen
dc.contributor.authorMarathe, Achlaen
dc.contributor.authorLewis, Bryan L.en
dc.contributor.authorBarrett, Christopher L.en
dc.contributor.authorChen, Jiangzhuoen
dc.contributor.authorMarathe, Madhav V.en
dc.contributor.authorEubank, Stephenen
dc.contributor.authorMa, Yifeien
dc.date.accessed2014-05-05en
dc.date.accessioned2014-06-17T20:12:06Zen
dc.date.available2014-06-17T20:12:06Zen
dc.date.issued2011-09-22en
dc.description.abstractThis research compares the performance of bottom-up, self-motivated behavioral interventions with top-down interventions targeted at controlling an “Influenza-like-illness”. Both types of interventions use a variant of the ring strategy. In the first case, when the fraction of a person's direct contacts who are diagnosed exceeds a threshold, that person decides to seek prophylaxis, e.g. vaccine or antivirals; in the second case, we consider two intervention protocols, denoted Block and School: when a fraction of people who are diagnosed in a Census Block (resp., School) exceeds the threshold, prophylax the entire Block (resp., School). Results show that the bottom-up strategy outperforms the top-down strategies under our parameter settings. Even in situations where the Block strategy reduces the overall attack rate well, it incurs a much higher cost. These findings lend credence to the notion that if people used antivirals effectively, making them available quickly on demand to private citizens could be a very effective way to control an outbreak.en
dc.description.sponsorshipNational Science Foundationen
dc.description.sponsorshipDivision of Computer and Network Systemsen
dc.description.sponsorshipDivision of Social and Economic Sciencesen
dc.description.sponsorshipOffice of Cyberinfrastructureen
dc.description.sponsorshipDefense Threat Reduction Agencyen
dc.description.sponsorshipNaval Surface Warfare Center Dahlgren Divisionen
dc.description.sponsorshipNational Institutes of Healthen
dc.description.sponsorshipNational Institute of Allergy and Infectious Diseasesen
dc.description.sponsorshipCNS-0626964en
dc.description.sponsorshipSES-0729441en
dc.description.sponsorshipOCI-0904844en
dc.description.sponsorshipCNS-0831633en
dc.description.sponsorshipCNS-0845700en
dc.description.sponsorshipCNS-1011769en
dc.description.sponsorshipOCI-1032677en
dc.description.sponsorshipHDTRA1-0901-0017en
dc.description.sponsorshipHDTRA1-07-C-0113en
dc.description.sponsorshipDE-SC0003957en
dc.description.sponsorshipN00178-09-D-3017 DEL ORDER 13en
dc.description.sponsorship2U01GM070694-7en
dc.description.sponsorshipHHSN272201000056Cen
dc.identifier.citationMarathe A, Lewis B, Barrett C, Chen J, Marathe M, et al. (2011) Comparing Effectiveness of Top-Down and Bottom-Up Strategies in Containing Influenza. PLoS ONE 6(9): e25149.en
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0025149en
dc.identifier.issn1932-6203en
dc.identifier.urihttp://hdl.handle.net/10919/48986en
dc.identifier.urlhttp://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0025149en
dc.language.isoen_USen
dc.publisherPublic Library of Scienceen
dc.rightsIn Copyrighten
dc.rights.urihttp://rightsstatements.org/vocab/InC/1.0/en
dc.subjectAntiviral therapeuticsen
dc.subjectDiagnostic medicineen
dc.subjectProphylaxisen
dc.subjectPublic and occupational healthen
dc.subjectPublic policyen
dc.subjectSchoolsen
dc.subjectSocial networksen
dc.subjectVaccinesen
dc.titleComparing Effectiveness of Top-Down and Bottom-Up Strategies in Containing Influenzaen
dc.title.serialPLoS ONEen
dc.typeArticle - Refereeden

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Scholarly Works, Fralin Life Sciences Institute
Destination Area: Data and Decisions (D&D)
Destination Area: Global Systems Science (GSS)