A Landscape Epidemiological Approach for Predicting Chronic Wasting Disease: A Case Study in Virginia, US

Simple item page
dc.contributor.authorWinter, Steven N.en
dc.contributor.authorKirchgessner, Megan S.en
dc.contributor.authorFrimpong, Emmanuel A.en
dc.contributor.authorEscobar, Luis E.en
dc.coverage.countryUnited Statesen
dc.coverage.stateVirginiaen
dc.date.accessioned2022-04-04T17:44:37Zen
dc.date.available2022-04-04T17:44:37Zen
dc.date.issued2021-08-24en
dc.description.abstractMany infectious diseases in wildlife occur under quantifiable landscape ecological patterns useful in facilitating epidemiological surveillance and management, though little is known about prion diseases. Chronic wasting disease (CWD), a fatal prion disease of the deer family Cervidae, currently affects white-tailed deer (Odocoileus virginianus) populations in the Mid-Atlantic United States (US) and challenges wildlife veterinarians and disease ecologists from its unclear mechanisms and associations within landscapes, particularly in early phases of an outbreak when CWD detections are sparse. We aimed to provide guidance for wildlife disease management by identifying the extent to which CWD-positive cases can be reliably predicted from landscape conditions. Using the CWD outbreak in Virginia, US from 2009 to early 2020 as a case study system, we used diverse algorithms (e.g., principal components analysis, support vector machines, kernel density estimation) and data partitioning methods to quantify remotely sensed landscape conditions associated with CWD cases. We used various model evaluation tools (e.g., AUC ratios, cumulative binomial testing, Jaccard similarity) to assess predictions of disease transmission risk using independent CWD data. We further examined model variation in the context of uncertainty. We provided significant support that vegetation phenology data representing landscape conditions can predict and map CWD transmission risk. Model predictions improved when incorporating inferred home ranges instead of raw hunter-reported coordinates. Different data availability scenarios identified variation among models. By showing that CWD could be predicted and mapped, our project adds to the available tools for understanding the landscape ecology of CWD transmission risk in free-ranging populations and natural conditions. Our modeling framework and use of widely available landscape data foster replicability for other wildlife diseases and study areas.en
dc.description.notesThis study was supported by a grant from the Rural Health Initiative of the Destination Areas/Strategic Growth Areas, Virginia Tech, and the Optimization of CWD Surveillance, Management and Communication Strategies in Virginia, Virginia Department ofWildlife Resources.en
dc.description.sponsorshipRural Health Initiative of the Destination Areas/Strategic Growth Areas, Virginia Tech; Optimization of CWD Surveillance, Management and Communication Strategies in Virginia, Virginia Department of Wildlife Resourcesen
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fvets.2021.698767en
dc.identifier.eissn2297-1769en
dc.identifier.pmid34504887en
dc.identifier.urihttp://hdl.handle.net/10919/109531en
dc.identifier.volume8en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectchronic wasting diseaseen
dc.subjectCWDen
dc.subjectwildlife diseaseen
dc.subjectlandscape epidemiologyen
dc.subjectprionen
dc.subjecthypervolumeen
dc.titleA Landscape Epidemiological Approach for Predicting Chronic Wasting Disease: A Case Study in Virginia, USen
dc.title.serialFrontiers in Veterinary Scienceen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
fvets-08-698767.pdf
Size:
3.67 MB
Format:
Adobe Portable Document Format
Description:
Published version
Download

Collections

Scholarly Works, Fish and Wildlife Conservation
Scholarly Works, Center for Emerging, Zoonotic, and Arthropod-borne Pathogens (CeZAP)
Scholarly Works, Global Change Center