Development of a Multi-Pulse Conductivity Model for Liver Tissue Treated With Pulsed Electric Fields

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dc.contributor.authorZhao, Yajunen
dc.contributor.authorZheng, Shuangen
dc.contributor.authorBeitel-White, Natalieen
dc.contributor.authorLiu, Hongmeien
dc.contributor.authorYao, Chenguoen
dc.contributor.authorDavalos, Rafael V.en
dc.contributor.departmentElectrical and Computer Engineeringen
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.date.accessioned2020-08-14T15:02:05Zen
dc.date.available2020-08-14T15:02:05Zen
dc.date.issued2020-05-19en
dc.description.abstractPulsed electric field treatment modalities typically utilize multiple pulses to permeabilize biological tissue. This electroporation process induces conductivity changes in the tissue, which are indicative of the extent of electroporation. In this study, we characterized the electroporation-induced conductivity changes using all treatment pulses instead of solely the first pulse as in conventional conductivity models. Rabbit liver tissue was employed to study the tissue conductivity changes caused by multiple, 100 mu s pulses delivered through flat plate electrodes. Voltage and current data were recorded during treatment and used to calculate the tissue conductivity during the entire pulsing process. Temperature data were also recorded to quantify the contribution of Joule heating to the conductivity according to the tissue temperature coefficient. By fitting all these data to a modified Heaviside function, where the two turning points (E-0, E-1) and the increase factor (A) are the main parameters, we calculated the conductivity as a function of the electric field (E), where the parameters of the Heaviside function (A and E-0) were functions of pulse number (N). With the resulting multi-factor conductivity model, a numerical electroporation simulation can predict the electrical current for multiple pulses more accurately than existing conductivity models. Moreover, the saturating behavior caused by electroporation can be explained by the saturation trends of the increase factor A in this model. The conductivity change induced by electroporation has a significant increase at about the first 30 pulses, then tends to saturate at 0.465 S/m. The proposed conductivity model can simulate the electroporation process more accurately than the conventional conductivity model. The electric field distribution computed using this model is essential for treatment planning in biomedical applications utilizing multiple pulsed electric fields, and the method proposed here, relating the pulse number to the conductivity through the variables in the Heaviside function, may be adapted to investigate the effect of other parameters, like pulse frequency and pulse width, on electroporation.en
dc.description.notesThis work was supported by grants from the National Institute of Health award R01 CA240476 and the National Natural Science Foundation of China (51877022).en
dc.description.sponsorshipNational Institute of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 CA240476]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [51877022]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fbioe.2020.00396en
dc.identifier.issn2296-4185en
dc.identifier.other396en
dc.identifier.pmid32509742en
dc.identifier.urihttp://hdl.handle.net/10919/99717en
dc.identifier.volume8en
dc.language.isoenen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectpulsed electric fielden
dc.subjectelectroporationen
dc.subjectdynamic processen
dc.subjectcumulative effecten
dc.subjecttissue conductivityen
dc.subjecttumor ablationen
dc.subjecttreatment planningen
dc.titleDevelopment of a Multi-Pulse Conductivity Model for Liver Tissue Treated With Pulsed Electric Fieldsen
dc.title.serialFrontiers In Bioengineering and Biotechnologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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