Induction of tolerance by oral administration of factor VIII and treatment of hemophilia

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dc.contributor.assigneeThe United States of America as represented by the Department of Health and Human Servicesen
dc.contributor.assigneeVirginia Tech Intellectual Properties, Inc.en
dc.contributor.inventorVelander, William H.en
dc.contributor.inventorMatzinger, Pollyen
dc.contributor.inventorAlpan, Oralen
dc.contributor.inventorKamala, Tirumalaien
dc.date.accessed2016-08-19en
dc.date.accessioned2016-08-24T17:55:02Zen
dc.date.available2016-08-24T17:55:02Zen
dc.date.filed2007-04-12en
dc.date.issued2011-01-11en
dc.description.abstractDisclosed herein is a simple method for the treatment of antigen-deficiency diseases, by orally administering to a subject a therapeutically effective amount of the deficient antigen, wherein the antigen is not present in a liposome. In one embodiment, the method increases hemostasis in a subject having hemophilia A or B, by orally administering to the hemophiliac a therapeutically effective amount of the appropriate clotting factor other than in a liposome, sufficient to induce oral tolerance and supply exogenous clotting factor to the subject.en
dc.format.mimetypeapplication/pdfen
dc.identifier.applicationnumber11734489en
dc.identifier.patentnumber7867974en
dc.identifier.urihttp://hdl.handle.net/10919/72656en
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/74/679/078/0.pdfen
dc.language.isoen_USen
dc.publisherUnited States Patent and Trademark Officeen
dc.subject.cpcA61K38/36en
dc.subject.cpcA61K38/27en
dc.subject.cpcA61K38/4846en
dc.subject.cpcA61K48/00en
dc.subject.cpcC12N2799/022en
dc.subject.cpcC12N2799/025en
dc.subject.cpcC12N2799/027en
dc.subject.uspc514/14.1en
dc.subject.uspcother530/383en
dc.titleInduction of tolerance by oral administration of factor VIII and treatment of hemophiliaen
dc.typePatenten
dc.type.dcmitypeTexten
dc.type.patenttypeutilityen

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