Transgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factor

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dc.contributor.assigneeVirginia Polytechnic Institute and State Universityen
dc.contributor.assigneeAmerican National Red Crossen
dc.contributor.inventorDrohan, William N.en
dc.contributor.inventorVelander, William H.en
dc.contributor.inventorLubon, Henryken
dc.date.accessed2016-08-19en
dc.date.accessioned2016-08-24T17:54:13Zen
dc.date.available2016-08-24T17:54:13Zen
dc.date.filed1999-03-04en
dc.date.issued2001-07-03en
dc.description.abstractA non-human transgenic mammalian animal, as described above, contains an exogenous double stranded DNA sequence stably integrated into the genome of the animal, which comprises cis-acting regulatory units operably linked to a DNA sequence encoding human Factor VIII protein and a signal peptide, where the cis-acting regulatory units are active in mammary gland cells and the signal peptide is active in directing newly expressed Factor VIII into the milk of the animal. The promoter may be a milk protein promoter such as for whey acidic protein, casein, lactalbumin, or beta-lactoglobulin promoter. The transgenic mammals are preferably farm animals, for example, cows, goats, sheep, rabbits and pigs. Concurrent expression of a gene for human von Willebrand's Factor into milk may be used to stabilize newly-secreted Factor VIII.en
dc.format.mimetypeapplication/pdfen
dc.identifier.applicationnumber9262017en
dc.identifier.patentnumber6255554en
dc.identifier.urihttp://hdl.handle.net/10919/72431en
dc.identifier.urlhttp://pimg-fpiw.uspto.gov/fdd/54/555/062/0.pdfen
dc.language.isoen_USen
dc.publisherUnited States Patent and Trademark Officeen
dc.subject.cpcA01K67/0278en
dc.subject.cpcA01K2207/15en
dc.subject.cpcA01K2217/00en
dc.subject.cpcA01K2217/05en
dc.subject.cpcA01K2227/10en
dc.subject.cpcA01K2227/105en
dc.subject.cpcA01K2267/01en
dc.subject.cpcC07K14/755en
dc.subject.cpcC12N15/8509en
dc.subject.uspc435/69.6en
dc.subject.uspcother800/14en
dc.subject.uspcother800/7en
dc.subject.uspcother800/15en
dc.subject.uspcother800/16en
dc.subject.uspcother800/17en
dc.subject.uspcother800/18en
dc.subject.uspcother800/25en
dc.titleTransgenic non-human mammals expressing human coagulation factor VIII and von Willebrand factoren
dc.typePatenten
dc.type.dcmitypeTexten
dc.type.patenttypeutilityen

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