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Bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic or artificial cavitation nuclei

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dc.contributor.authorEdsall, Connoren
dc.contributor.authorKhan, Zerin Mahzabinen
dc.contributor.authorMancia, Laurenen
dc.contributor.authorHall, Sarahen
dc.contributor.authorMustafa, Waleeden
dc.contributor.authorJohnsen, Ericen
dc.contributor.authorKlibanov, Alexander L.en
dc.contributor.authorDurmaz, Yasemin Yukselen
dc.contributor.authorVlaisavljevich, Elien
dc.contributor.departmentBiomedical Engineering and Mechanicsen
dc.contributor.departmentInstitute for Critical Technology and Applied Scienceen
dc.date.accessioned2021-05-05T15:33:44Zen
dc.date.available2021-05-05T15:33:44Zen
dc.date.issued2021-03en
dc.description.abstractThe study described here examined the effects of cavitation nuclei characteristics on histotripsy. High-speed optical imaging was used to compare bubble cloud behavior and ablation capacity for histotripsy generated from intrinsic and artificial cavitation nuclei (gas-filled microbubbles, fluid-filled nanocones). Results showed a significant decrease in the cavitation threshold for microbubbles and nanocones compared with intrinsic-nuclei controls, with predictable and well-defined bubble clouds generated in all cases. Red blood cell experiments showed complete ablations for intrinsic and nanocone phantoms, but only partial ablation in microbubble phantoms. Results also revealed a lower rate of ablation in artificial-nuclei phantoms because of reduced bubble expansion (and corresponding decreases in stress and strain). Overall, this study demonstrates the potential of using artificial nuclei to reduce the histotripsy cavitation threshold while highlighting differences in the bubble cloud behavior and ablation capacity that need to be considered in the future development of these approaches. (E-mail: cwedsall@vt.edu) (C) 2020 The Author(s). Published by Elsevier Inc. on behalf of World Federation for Ultrasound in Medicine & Biology.en
dc.description.notesThe research reported in this publication was supported by the National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (NIH) under Award No. R21 EB027979. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This work was also supported by a Junior Faculty Award from the Virginia Tech Institute for Critical Technology and Applied Science (ICTAS). A.L. Klibanov is supported in part via NIH R01 EB023055. Y. Yuskel Durmaz was supported by the Scientific & Technological Research Council of Turkey (TUBITAK) for nanocone preparation (Project No. 118 Z324) and the Turkish Academy of Sciences through its Outstanding Young Scientist Award Program (TUBA-GEBIP). L. Mancia and E. Johnsen are supported in part by ONR Grant No. N00014-18-1-2625.en
dc.description.sponsorshipNational Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (NIH) [R21 EB027979]; Junior Faculty Award from the Virginia Tech Institute for Critical Technology and Applied Science (ICTAS); NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [R01 EB023055]; Scientific & Technological Research Council of Turkey (TUBITAK)Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [118 Z324]; Turkish Academy of Sciences through its Outstanding Young Scientist Award Program (TUBA-GEBIP); ONROffice of Naval Research [N00014-18-1-2625]en
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1016/j.ultrasmedbio.2020.10.020en
dc.identifier.eissn1879-291Xen
dc.identifier.issn0301-5629en
dc.identifier.issue3en
dc.identifier.urihttp://hdl.handle.net/10919/103196en
dc.identifier.volume47en
dc.language.isoenen
dc.rightsCreative Commons Attribution-NonCommercial-NoDerivs 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectHistotripsyen
dc.subjectMicrotripsyen
dc.subjectNanoparticlesen
dc.subjectMicrobubblesen
dc.subjectCavitationen
dc.subjectAblationen
dc.titleBubble cloud behavior and ablation capacity for histotripsy generated from intrinsic or artificial cavitation nucleien
dc.title.serialUltrasound in Medicine and Biologyen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten
dc.type.dcmitypeStillImageen

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