Focused ultrasound for the remote modulation of nitric oxide release from injectable PEG-fibrinogen hydrogels for tendon repair

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dc.contributor.authorMeyers, Kaylee M.en
dc.contributor.authorSimon, Alexen
dc.contributor.authorKhan, Zerin M.en
dc.contributor.authorRajachar, Rupak M.en
dc.contributor.authorVlaisavljevich, Elien
dc.date.accessioned2023-08-25T19:42:57Zen
dc.date.available2023-08-25T19:42:57Zen
dc.date.issued2023-04en
dc.description.abstractIntroduction: Tendon disorders such as tendinosis, the degradation of collagen in tendon, or tendonitis, inflammation of tendon tissue, contribute to 30% of musculoskeletal complaints. To address the limitations of currently available treatments for tendon repair, an injectable polyethylene glycol (PEG)fibrinogen hydrogel encompassing nitric oxide (NO) releasing mu-particles was generated. The release of nitric oxide, a therapeutic molecule that modulates many wound healing processes, from the hydrogel can be modified with thermal and mechanical stimulus. To achieve remote control over NO release from hydrogels after deployment, focused ultrasound (FUS) was explored as it provides highly controlled thermal and mechanical stimulus non-invasively. Methods: In this work, the ability of FUS to remotely elicit on-demand NO generation from acoustically active composite hydrogels via thermal and/or mechanical stimulus was explored. Specifically, the temperature and timedependent release of NO was simulated and characterized when applying FUS to composite hydrogels. Results: Results from acoustic simulations as well as thermocouple heating studies indicated that high spatial and temporal control over hydrogel warming could be achieved non-invasively with a 3.5 MHz FUS transducer. FUS was also able to remotely control NO release from hydrogels with various thermal magnitudes and durations. Additionally, no apparent changes in the mechanical properties of hydrogels were observed with FUS treatment. Discussion: Utilizing FUS thermal and mechanical stimulus provides a potential method of remotely controlling NO release from hydrogels at a wound site to aid in tendon repair.en
dc.description.notesThis work was supported in part by grants from the NIH (R15-GM112082 and R15-GM137298) (RR), the Focused Ultrasound Foundation through the Charles Steger Global Internship Program (KM), and the Barry Goldwater Scholarship and Excellence in Education Foundation (KM).en
dc.description.sponsorshipNIH [R15-GM112082, R15-GM137298]; Focused Ultrasound Foundation through the Charles Steger Global Internship Program; Barry Goldwater Scholarship and Excellence in Education Foundationen
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.3389/fmats.2023.1159444en
dc.identifier.issn2296-8016en
dc.identifier.other1159444en
dc.identifier.urihttp://hdl.handle.net/10919/116134en
dc.identifier.volume10en
dc.language.isoenen
dc.publisherFrontiersen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectnitric oxideen
dc.subjectcomposite hydrogelsen
dc.subjecttendon repairen
dc.subjectfocused ultrasound (FUS)en
dc.subjectstimuliresponsiveen
dc.titleFocused ultrasound for the remote modulation of nitric oxide release from injectable PEG-fibrinogen hydrogels for tendon repairen
dc.title.serialFrontiers in Materialsen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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