Time-keeping and decision-making in living cells: Part I

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dc.contributor.authorTyson, John J.en
dc.contributor.authorCsikasz-Nagy, Attilaen
dc.contributor.authorGonze, Didieren
dc.contributor.authorKim, Jae Kyoungen
dc.contributor.authorSantos, Silviaen
dc.contributor.authorWolf, Janaen
dc.date.accessioned2022-07-07T14:51:05Zen
dc.date.available2022-07-07T14:51:05Zen
dc.date.issued2022-04-15en
dc.description.abstractTo survive and reproduce, a cell must process information from its environment and its own internal state and respond accordingly, in terms of metabolic activity, gene expression, movement, growth, division and differentiation. These signal-response decisions are made by complex networks of interacting genes and proteins, which function as biochemical switches and clocks, and other recognizable information-processing circuitry. This theme issue of Interface Focus (in two parts) brings together articles on time-keeping and decision-making in living cells-work that uses precise mathematical modelling of underlying molecular regulatory networks to understand important features of cell physiology. Part I focuses on time-keeping: mechanisms and dynamics of biological oscillators and modes of synchronization and entrainment of oscillators, with special attention to circadian clocks.en
dc.description.versionPublished versionen
dc.format.mimetypeapplication/pdfen
dc.identifier.doihttps://doi.org/10.1098/rsfs.2022.0011en
dc.identifier.eissn2042-8901en
dc.identifier.issn2042-8898en
dc.identifier.issue3en
dc.identifier.other20220011en
dc.identifier.urihttp://hdl.handle.net/10919/111153en
dc.identifier.volume12en
dc.language.isoenen
dc.publisherRoyal Societyen
dc.rightsCreative Commons Attribution 4.0 Internationalen
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en
dc.subjectmolecular regulatory networksen
dc.subjectfeedback loopsen
dc.subjectmathematical modellingen
dc.subjectmulti-rhythmicityen
dc.subjectentrainmenten
dc.subjectcircadian rhythmsen
dc.titleTime-keeping and decision-making in living cells: Part Ien
dc.title.serialInterface Focusen
dc.typeArticle - Refereeden
dc.type.dcmitypeTexten

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